尼莫地平和硝普钠治疗高血压性脑病的临床疗效和不良反应观察  

To Observe the Clinical Efficacy and Adverse Reactions of Nimodipine and Sodium Nitroprusside in the Treatment of Hypertensive Encephalopathy

作　　者：刘文友[1] 梅吉峰 杨林[2] 

机构地区：[1]中国人民解放军93307部队医院 [2]辽宁省人民医院心内科

出　　处：《中国继续医学教育》2015年第20期171-172,共2页China Continuing Medical Education

摘　　要：目的探讨分析尼莫地平和硝普钠治疗高血压性脑病的临床疗效和不良反应、方法随机选取2009年7月～2011年10月因高血压性脑出血就诊于我院的患者130例，随机分为治疗组（采用尼莫地平治疗）65例患者，对照组（采用硝普钠治疗）65例患者，观察总结两组患者治疗的效果及不良反应发生情况，并对两组结果进行统计学分析。结果两组方法对高血压性脑病治疗均有效，但是治疗组有效率为84．6％，治疗效果好于对照组，治疗组不良反应发生率为9．2％；低于对照组，经统计分析。P〈0.05，差异有统计学意义。结论尼莫地平和硝普钠两种药物对高血压性脑病均有治疗作用，尼莫地平的治疗效果更好，并且不良反应发生率更低，更安全。Objective To analyze the clinical efficacy and adverse reactions of nimodipine and sodium nitroprusside for the treatment of hypertensive encephalopathy. Methods 130 patients with hypertensive cerebral hemorrhage were randomly selected in our hospital from July 2009 to October 2011, they were randomly divided into treatment group （treated with nimodipine） 65 patients, control group （treated with sodium nitroprusside） 65 patients, the clinical efficacy and adverse reactions were observed, the results of the two groups were statistically analyzed. Results Both of the methods were effective for the treatrnent of hypertensive encephalopathy, but in the treatment group, the efficiency was 84.6%. The treatment effect was significantly better than the control group, The incidence of adverse reaction was 9.2%, it was significantly lower than the control group. After statistical analysis, P〈0.05, there was statistical significance. Conclusion Nimodipine and sodium nitroprusside are both effective for the treatment of hypertensive encephalopathy, the effect of nimodipine is better, and the incidence of adverse reaction is lower, it is more secure.

关 键 词：尼莫地平 硝普钠 高血压性脑病 

分 类 号：R544[医药卫生—心血管疾病]