延迟应用重组人促红细胞生成素治疗大鼠急性挤压性胸脊髓损伤  被引量:1

The effects of recombinant human erythropoietin on thoracic acute spinal cord compressive injury in rats: delayed treatment

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作  者:严鑫平 杨刘柱 吴波[1] 陈仲[1] 谭伟[1] 

机构地区:[1]南方医科大学珠江医院骨科中心,广州市510280 [2]贺州市人民医院脊柱骨科,贺州市542899

出  处:《实用医学杂志》2015年第14期2258-2261,共4页The Journal of Practical Medicine

基  金:广东省科技计划项目(编号:2011B031300005);广州市海珠区科技计划项目(编号:2011-YL-01)

摘  要:目的:评估延迟应用重组人促红细胞生成素(rhEPO)治疗大鼠急性挤压性胸脊髓损伤的神经保护作用。方法:将16只健康成年雄性SD大鼠随机分为对照组(SCI组)和实验组(rhEPO组),SCI组在脊髓损伤后2 h,术后第1、3天给予生理盐水治疗,而实验组则在损伤后2 h,术后第1、3天给予rhEPO(3 000 U/kg)治疗,共观察4 d。主要研究指标有BBB评分、凋亡指数、炎症指数及电镜研究。结果 :延迟应用rhEPO可以抑制细胞凋亡,调节炎症反应,改善脊髓损伤的超微结构,改善运动功能。结论:延迟应用rhEPO治疗大鼠急性脊髓损伤具有神经保护效应。Objective To investigate the neuroprotection of delayed treatment of thoracic acute spinal cord injury with recombinant human erythropoietin (rhEPO) in rat model of compressive injury. Methods Sixteen aduh male Sprague-Dawley rats were randomly divided into two groups: control group (compressive injury group) and experimental group (rhEPO group), In the compressive injury group,the animals recived 0.9% saline treatment at 2 h, day 1 and day 3 after the injury, while in the rhEPO group, rhEPO (3 000 U/kg) was given to rats at 2 h, day 1 and day 3 after the injury. All the rats were observed in 4 days after the injury. The primary outcomes were evaluated by BBB scale, apoptotic index, inflammatory index and electron microscopy. Results Delayed treatment of thoracic acute spinal cord injury with rhEPO could reduce apoptosis, regulate inflammation, improve motor function and promote regeneration of the spinal cord. Conclusion Our study suggests that delayed treatment of thoracic spinal cord compressive injury with rhEPO could exert neuroprotection.

关 键 词:促红细胞生成素 延迟治疗 脊髓损伤 神经保护作用 

分 类 号:R651.2[医药卫生—外科学]

 

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