宣肺中药对慢性阻塞性肺疾病大鼠多脏器病理影响  

Effects of TCM medicine on multiple organs

作　　者：徐晓杰[1] 

机构地区：[1]南阳医学高等专科学校,河南南阳473003

出　　处：《中医临床研究》2015年第20期107-108,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨应用"宣肺"中药治疗多脏器病理改变的慢性阻塞性肺疾病大鼠的疗效。方法:选取健康雄性SPF级Wistar大鼠60只,随机分为给药组、模型组及对照组,各20只,给药组和模型组采用改良烟熏加气管滴注脂多糖加的方法复制慢性阻塞性肺疾病模型,观察大鼠肺及肠道等组织的病理变化,应用实验室检测手段检测大鼠支气管肺泡灌洗液中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平,以及服用宣肺中药治疗后上述病理及实验室指标变化。结果:三组大鼠之间TNF-α、IL-1β差异有统计学意义(P<0.05)。结论:宣肺中药对阻塞性肺疾病治疗效果良好。Objective： To discuss effects of the Xuanfei chinese medicine on multiple organ pathology of chronic obstructive pulmonary disease from rats. Methods： Wistar male rats of SPF 60 and randomly divided into the treatment group, the model group and the control group. Treatment group and the untreated group was given smoked plus LPS plus modified method of copying trachea drops of chronic obstructive pulmonary disease models. The pathological changes observed in rat lung and intestinal and other organizations, the application of laboratory testing methods to detect rat bronchoalveolar lavage fluid interleukin-1β（IL-1β）, tumor necrosis factor-α（TNF-α） levels, after taking Xuanfei intestinal propulsion rates and pathology and laboratory medicine treatment of these indicators change. Results： There was statistically significance difference between the three groups of rats TNF- alpha, IL-1β（P〈0.05）. Conclusion： TCM medicine shows good effects.

关 键 词：宣肺 肺合大肠 慢性阻塞性肺疾病 WISTAR大鼠 

分 类 号：R256.1[医药卫生—中医内科学]