PF4和β-TG在KD发病机制及CAL中的作用分析  

Analysis on the roles of PF4 and β-TG in pathogenesis of KD and CAL

作　　者：季雪红 赵冬梅 米尔扎提.海维尔 

机构地区：[1]新疆维吾尔自治区乌鲁木齐市第一人民医院风湿免疫科,830000

出　　处：《中国妇幼保健》2015年第23期3975-3977,共3页Maternal and Child Health Care of China

基　　金：新疆维吾尔自治区乌鲁木齐市科学技术计划项目〔Y111310022〕

摘　　要：目的探讨血小板第4因子(PF4)、β-血小板球蛋白(β-TG)在川崎病(KD)及冠状动脉损伤(CAL)中的机制和作用。方法以该院收集的44例KD患儿作为KD组,同期健康儿童30例作为对照组,检测并比较两组儿童的PF4、β-TG等指标的差异;将KD患儿根据是否伴有CAL分为CAL组(13例)和非CAL组(31例),比较两组KD患儿的PF4、β-TG等指标的差异;并比较KD患儿治疗前后的PF4、β-TG等指标的差异。结果 KD组患儿的PF4、β-TG、WBC、PBN、PLT、CRP、ESR、AST、APTT、PT值均显著高于健康组儿童,差异均具有统计学意义(P<0.05)。治疗前CAL患儿的PF4(5.36±0.41)ng/ml、β-TG(21.14±2.08)ng/ml均显著高于非CAL患儿的(4.72±0.38)ng/ml、(17.25±1.95)ng/ml,差异均具有统计学意义(P<0.05)。治疗后KD患儿的PF4、β-TG测定值比较值分别为(3.32±0.49)ng/ml、(12.08±2.09)ng/ml,均显著的低于治疗前,差异均具有统计学意义(P<0.05)。结论血PF4、β-TG在KD患儿的表达水平显著高于健康儿童,CAL患儿的血PF4、β-TG水平显著高于非CAL患儿,治疗后KD患儿的PF4、β-TG水平显著降低,临床上可把PF4、β-TG明显增高作为KD患儿并发CAL的危险因素指标,PF4、β-TG也可作为判定CAL疗效及随访指标。Objective To explore the mechanisms and roles of platelet factor fourth（ PF4） and β thromboglobulin（ β- TG） in pathogenesis of Kawasaki disease（ KD） and coronary artery lesion（ CAL）. Methods Forty- four KD children were collected from the hospital as KD group,thirty healthy children were collected during the same period as control group; the levels of PF4 and β- TG were detected and compared; the KD children were divided into CAL group（ 13 children） and non- CAL group（ 31 children） according to combining with CAL or not; the levels of PF4 and β- TG in the two KD groups were detected and compared; the levels of PF4 and β- TG before and after treatment in children with KD were compared. Results The levels of PF4,β- TG,WBC,PBN,PLT,CRP,ESR,AST,APTT,and PT in children with KD were statistically significantly higher than those in control group（ P〈0. 05）. Before treatment,the levels of PF4 and β- TG in CAL group were（ 5. 36 ± 0. 41） ng / ml and（ 21. 14 ± 2. 08） ng / ml,respectively,which were statistically significantly higher than those in non- CAL group 〔（ 4. 72 ± 0. 38） ng / ml and（ 17. 25 ± 1. 95） ng / ml,respectively〕（ P〈0. 05）; among the KD children,the comparison values of PF4 and β- TG after treatment were（ 3. 32 ± 0. 49） ng / ml and（ 12. 08 ± 2. 09） ng / ml,respectively,which were statistically significantly lower than those before treatment（ P〈0. 05）. Conclusion The expression levels of PF4 and β- TG in children with KD were significantly higher than those in healthy children,the levels of PF4 and β- TG in children with CAL were significantly higher than those in children without CAL,after treatment,the levels of PF4 and β- TG in children with KD decreased significantly; significant upregulation of PF4 and β- TG levels can be used as risk indexes of KD children combining with CAL,which can be used to determine the curative effect on CAL and follow- up.

关 键 词：血小板第4因子 Β-血小板球蛋白 川崎病 冠状动脉损伤 

分 类 号：R725.4[医药卫生—儿科]