中药注射剂过敏反应体外实验研究进展  

In vitro experiment of allergic reactions induced by traditional Chinese medicine injections

作　　者：康瑞霞[1] 游蓉丽[1] 王蕾[1] 雷蕾[2] 王忠[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院中医药信息研究所,北京100700

出　　处：《中国中药杂志》2015年第13期2503-2507,共5页China Journal of Chinese Materia Medica

基　　金：中国中医科学院自主选题项目(Z0296)

摘　　要：中药注射剂引起的过敏反应是目前影响中药注射剂临床使用安全的最大障碍,常用的临床前评价中药注射剂过敏反应的整体动物评价法存在灵敏度低、特异性差、周期长、观察指标不够客观等缺陷,因此,应用体外检测法研究中药注射剂的过敏反应受到越来越多研究者的重视。目前,体外评价中药注射剂过敏反应的方法主要是针对其引起的类过敏反应和Ⅰ型过敏反应,仅有少量针对中药注射剂引起Ⅱ型过敏反应的体外评价方法,该文对近年来发表的关于中药注射剂过敏反应体外评价方法的相关文献进行了综述。Allergic reactions caused by traditional Chinese medicine injections （TCMIs） become a greatest concern in the clinic ap- plication safety. The integral animal evaluation method commonly used in the preclinical evaluation for allergic reactions of TCMIs was not sensitive, specific, quick and objective in observation indexes. Therefore, more researchers have paid attention to the in vitro test method for evaluating allergic reactions induced by TCMIs. Currently, the methods for evaluating allergic reactions induced by TCMIs are mainly targeted at type I allergic reaction and anaphylactic reaction, with only a few in vitro methods for evaluating type Ⅱ allergic reaction. In this paper, researchers summarized relevant literatures published about evaluation methods for allergic reactions induced by TCMIs in recent years.

关 键 词：中药注射剂 过敏反应 体外实验 

分 类 号：R286[医药卫生—中药学]