芳酰腙和麦芽酚混合配体钒(Ⅴ)配合物的合成、表征、晶体结构及其类胰岛素活性（英文）  

Syntheses, Characterization, Crystal Structures and Insulin-Like Activity of Vanadium(Ⅴ) Complexes with Aroylhydrazone and Maltol Mixed-Ligands

作　　者：贺淼[1] 焦庆祝[1] 陈相飞 李健[2] 陈杰[2] 盛桂华[2] 由忠录[1] 

机构地区：[1]辽宁师范大学化学化工学院,大连116029 [2]山东理工大学生命科学学院,淄博255049

出　　处：《无机化学学报》2015年第8期1590-1596,共7页Chinese Journal of Inorganic Chemistry

基　　金：辽宁省高校优秀青年人才支持计划(No.LR2014032)资助项目

摘　　要：制备了2个钒配合物[VOLL1](1)和[VOLL2](2),其中L为N′-(3,5-二溴-2-羟基苯甲基)-3-甲基苯甲酰肼,L1为甲基麦芽酚,L2为乙基麦芽酚。通过物理化学方法和单晶X-射线衍射对配合物的结构进行了表征。在每个配合物中,钒原子都是由来自配体L中的3个配位原子,来自L1或L2中的2个配位原子,以及1个氧基配体进行配位的,形成八面体配位构型。将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这2个配合物在剂量为10.0和20.0 mgV·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而正常大鼠的血糖值却没有改变。Two vanadium（V） complexes, [VOLL1] （1） and [VOLL2] （2） （L=N＇-（3,5-dibromo-2-hydroxybenzylidene）- 3-methylbenzohydrazide, L1 =methylmahol, L2 =ethylmahol）, have been prepared. The complexes have been characte-rized by physico-chemical methods and single crystal X-ray determination. The V atom in each complex is coordinated by three donor atoms of L, two donor atoms of L1 or L2, and one oxo group, forming octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mices for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgv ·kg-1, can significantly decrease the blood glucose level in alloxan-diabetic mices, but the blood glucose level in the treated normal mices was not altered. CCDC： 1059791, 1; 1059793, 2.

关 键 词：钒配合物 芳酰腙 晶体结构 类胰岛素活性 

分 类 号：O614.511[理学—无机化学]