老年男性冠心病患者抑郁评分、血清性激素水平与冠脉Gensini评分的相关性  

Relationship study on depression score, serum levels of sex hormones and coronary Gensini score in old men with coronary heart disease

作　　者：张琼[1] 黄建华[1] 熊三军[1] 马江伟[2] 乔增勇[2] 张立[2] 刘化进[2] 程文波[2] 曹华[2] 

机构地区：[1]辽宁医学院奉贤区中心医院研究生培养基地,上海201400 [2]上海交通大学附属第六人民医院南院心内科

出　　处：《中华行为医学与脑科学杂志》2015年第7期611-614,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：上海市奉贤区卫生局青年基金项目（奉卫科（青）2010-01）

摘　　要：目的探讨老年男性冠心病患者的性激素的变化、抑郁状态与冠心病的发生及冠脉病变严重程度的相关性。方法单纯随机抽样法选取心内科住院的300例老年男性作为研究对象，根据有无冠心病，分为冠心病组（220例）和对照组（80例）。入院后先进行汉密顿抑郁量表（HAMD24版本）评分，并检测患者血清睾酮及雌二醇水平，造影后进行冠状动脉的Gensini评分。通过多元线性回归分析患者冠脉Gensini评分、汉密顿抑郁量表评分及血清睾酮、雌二醇水平之间的相关性。结果（1）冠心病组HAMD评分高于非冠心病组[分别为（23．82＋11．74）分，（21．25±10．54）分]，冠心病组血清T水平低于非冠心病组[分别为（11．23±4．46）ng／ml，（15．96±5．87）ng／m1]，差异有统计学意义（P〈0．05）。（2）睾酮与HAMD评分呈负相关（t=-3．562，P〈0．05），R2=0．041，F=12．960（P〈0．01）。（3）睾酮与Gensini评分呈负相关（t=-4．276，P〈0．01），R2=0．058，F=18．286（P〈0．01）。（4）雌二醇血清含量与HAMD评分无相关；（5）Genisini评分与HAMD评分呈正相关（t=-3．977P〈0．01），R。0．045，F=14．175（P〈0．01）。结论男性血清睾酮水平与冠状动脉病变程度、抑郁水平呈负相关；冠心病患者其冠脉病变程度与抑郁症的抑郁水平呈正相关。Objective To reveal the relevance of the elderly male sex hormone changes and the occur- rence of depression in the elderly, severity of coronary artery disease occurrence and sex hormone levels, depression status and coronary heart disease（CHD） in coronary heart disease patients. Methods Total of 300 elderly male patients underwent coronary angiography in the department of cardiology were collected, including 80 controls and 220 coronary heart disease patients. All coronary angiography elderly male patients admitted to hospital were ana- lyzed by Hamilton Depression Scale （HAMD24 version）, the patient＇s serum testosterone, estradiol levels and Gensini score of coronary after angiography were checked. The multiple linear regression analysis was used to in- vestigate the correlation among coronary Gensini score, Hamilton Depression Scale score and serum testosterone. Results （1） The HAMD scores in CHD group were higher than those in controls （（23.82±11.74） vs （21.25± 10.54） ） ,and testosterone level was lower than that in controls （ （11.23±4.46） ng/ml, （15.96±5.87） ng/ml,re- spectively）, the difference was statistically significant （P〈0.05）. （2）Testosterone and HAMD score was negatively correlated （ t=-3.562, P〈0.05） ,and the correlation coefficient （ R2） was 0.041, Fvalue was 12.960 （P〈0.01）. （3） Testosterone and HAMD score was negatively correlated （ t=-4.276, P〈0.05）, and the correlation coefficient （ R 2） was 0.058, F value was 18.286 （P〈0.01）. （4）Estradiol serum content and HAMD score showed no correla- tion. （5）Genisini scores were positively correlated with HAMD score （ t=-3.977, P〈0.05）,the correlation coeffi- cient （ R 2 ） was 0.045, F value was 14.175 （P〈0.01） .Conclusion Serum testosterone levels of the men are neg- atively correlated with coronary artery disease and depression levels. The degree of coronary artery lesions in pa- tients with coronary heart disease was positively correlated wit

关 键 词：男性 抑郁 血清性激素水平 冠脉Gensini评分 

分 类 号：R541.4[医药卫生—心血管疾病]