支气管哮喘-慢性阻塞性肺疾病重叠综合征患者血清维生素D水平的临床研究  

Clinical study of serum vitamin D levels in patients with asthma-chronic obstructive pulmonary disease overlap syndrome

作　　者：杨海华[1] 金先桥[1] 王桂芳[1] 朱柠[1] 章鹏[1] 李文静[1] 张霞[1] 龙丰[1] 

机构地区：[1]复旦大学附属华山医院北院呼吸科,上海201907

出　　处：《临床内科杂志》2015年第7期455-457,共3页Journal of Clinical Internal Medicine

基　　金：上海市卫生和计划生育委员会青年科研项目（20134Y003）

摘　　要：目的观察支气管哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者血清维生素D的水平情况，探讨维生素D不足或缺乏对ACOS患者的影响。方法收集ACOS患者和同期体检健康对照者各48例，采用酶联免疫吸附试验（EHSA）法测定其血清中的25-羟维生素D[25-（OH）D]水平；将ACOS患者的急性发作频率、第1秒用力呼气容积占预计值百分比（FEV，％）和25-（OH）D水平作相关分析。结果ACOS患者的血清中25-（OH）D水平[（32．26±9．97）nmol/L]明显低于对照组[（51．00±14．61）nmoVL，P〈0．05]。ACOS患者的25-（OH）D水平与其急性发作次数呈负相关（r=-0．70，P〈0．05），与患者FEV，％呈正相关（r=0．68，P〈0．05）。结论维生素D不足或缺乏在ACOS患者中患病率较高，且与ACOS患者的急性发作次数和FEV，％相关。Objective To observe the serum levels of vitamin D in patients with asthma-chronic obstructive pulmonary disease overlap syndrome （ACOS）, and to explore the effect of vitamin Ddeficiency or lack on the ACOS patients. Methods Forty-eight ACOS patients and forty-eight healthy subjects were enrolled in our study. The serum levels of 25-（OH） D were measured by enzyme-linked immunosorbent assay （ELISA）. The correlation analysis were used for the incidence of exacerbations, forced expiratory volume in one second to forced vital capacity ratio（FEV1% ） and the levels of 25-（OH）D in the ACOS patients. Results The levels of 25-（OH） D were significantly lower in the ACOS patients[ （32.26 ±9.97）nmol/L] than those in the healthy subjects [ （51.00±14.61 ） nmol/L, P 〈 0.05 ]. 25-（OH） D level was negatively correlated with the incidence of exacerbations （ r = - 0. 70, P 〈 0.05 ）, and positively correlated with FEV1 % （r = 0. 68, P 〈 0. 05 ）. Conclusion Vitamin D deficiency or lack is highly prevalent in the ACOS patients ,which may be correlated with the increased incidence of exacerbations and the declined level of FEV1 % in the ACOS patients.

关 键 词：支气管哮喘-慢性阻塞性肺疾病重叠综合征 维生素D 

分 类 号：R563[医药卫生—呼吸系统]