重组烟曲霉抗原4特异性IgE对变应性支气管肺曲菌病诊断价值的荟萃分析  

Diagnostic value of recombinant Aspergillus fumigatus allergen 4 specific IgE in allergic bronchop- ulmonary aspergillosis：a meta-analysis

作　　者：项宁[1] 胡林涛[1] 董翔[1] 祝戎飞[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院过敏反应科,武汉430030

出　　处：《临床内科杂志》2015年第7期458-461,共4页Journal of Clinical Internal Medicine

摘　　要：目的拟通过荟萃分析确定血清重组烟曲霉抗原4特异性IgE（rASPf4-sIgE）对变应性支气管肺曲菌病（ABPA）的诊断价值。方法收集相关文献，提取资料进行系统评价，用随机效应模型汇总各研究中rASPf4．sIgE诊断ABPA的准确性指标，绘制汇总受试者工作特征曲线并探讨其诊断特性。结果按照纳入标准有10项研究最终入选。rAsPf4-sIsE诊断ABPA的合并敏感度为0．824；特异度为0．966；阳性似然比为14．682；阴性似然比为0．206；诊断优势比为105．200。结论rASPf4-sIgE诊断ABPA的敏感度和特异度均高，测量血清中rASPf4-sIgE有助于诊断ABPA。分析rASPf4-sIgE结果需与其它临床表现及常规检验结果相结合。Objective To perform a meta-analysis to determine the accuracy of recombinant Aspergillus fumigatus allergen 4 specific immunoglobulin E（rASP f 4-sIgE） measurement in the diagnosis of allergic bronchopulmonary aspergillosis（ABPA）. Methods A systematic review of associated studies was conducted and data on the accuracy of rASP f 4-sIgE in sera for the diagnosis of ABPA were pooled using random effects models. Summary receiver operating characteristic curve was used to summarize overall test performance. Results Ten studies met our inclusion criteria. The summary estimation for rASP f 4-sIgE in the diagnosis of ABPA in the studies included were： sensitivity 0. 824, specificity 0.966, positive likelihood ratio 14. 682, negative likelihood ratio 0. 206 and diagnostic odds ratio 105. 200. Conclusion rASP f 4-slgE determination is a sensitive and specific test for the diagnosis of ABPA. Measurement of rASP f 4-sIgE in sera is thus likely to be a useful diagnostic tool for ABPA. The results of rASP f 4-sIgE assays should be interpreted in parallel with clinical findings and the results of conventional tests.

关 键 词：荟萃分析 变应性支气管肺曲菌病 重组曲霉菌抗原4 

分 类 号：R563.12[医药卫生—呼吸系统]