国内腹腔镜袖状胃切除术对肥胖合并2型糖尿病的近期疗效的Meta分析  

Short-Term Efficacy of Laparoscopic Sleeve Gastrectomy for Obesity with Type 2 Diabetes Mellitus in China: A Systematic Analysis

作　　者：杨志伟[1] 孙兆丹[2] 朱大勇[1] 毛晓光[1] 

机构地区：[1]黑龙江省医院香坊院区普外二科,黑龙江哈尔滨150036 [2]黑龙江省疾病预防控制中心免疫规划所,黑龙江哈尔滨150030

出　　处：《中国普外基础与临床杂志》2015年第8期942-947,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：黑龙江省卫生计生委科研课题(编号:2014-136)~~

摘　　要：目的探讨国内腹腔镜袖状胃切除术（LSG）对肥胖合并2型糖尿病（T2MD）的近期疗效。方法检索万方、知网中文数据库、Pub Med和Web of Science英文数据库,按照纳入和排除标准筛选文献,提取纳入文献中的相关数据,并对其进行方法学质量评价,对LSG治疗肥胖合并T2DM的近期疗效（术后空腹血糖和糖化血红蛋白水平）进行Meta分析。结果本研究共纳入7篇文献共计107例符合纳入条件的患者。Meta分析结果显示：1空腹血糖水平：术后6个月与术前比较以及术后12个月与术后6个月比较均明显下降（术后6个月与术前比较：MD=2.99,95%CI为2.39~3.60,P〈0.000 01;术后12个月与术后6个月比较：MD=0.56,95%CI为0.16~0.95,P=0.006）。2糖化血红蛋白水平：术后6个月与术前比较以及术后12个月与术后6个月比较均明显下降（术后6个月与术前比较：MD=2.24,95%CI为1.43~3.04,P〈0.000 01;术后12个月与术后6个月比较：MD=0.52,95%CI为0.22~0.81,P=0.000 6）。LSG术后患者空腹血糖和糖化血红蛋白呈下降趋势。结论 LSG治疗肥胖合并T2MD的近期疗效明显,其长期疗效还需要大样本临床随机对照研究数据支持。Objective To investigate the short-term efficacy of laparoscopic sleeve gastrectomy（LSG） for obesity with type 2 diabetes mellitus（T2MD） in China. Methods Clinical randomized controlled trial literatures about domestic LSG treatment of obesity with T2 MD were obtained from Wanfang Data, China Knowledge Resource Integrated Database,Pub Med and Web of Science English Data. The literatures were selected according to the inclusive and exclusive criteria, then evaluated. Methodological quality assessment and meta analysis were evaluated according to the data extracted from those literatures. The short-term efficacy（fasting blood glucose or glycosylated hemoglobin） was evaluated after operation. Results One hundred and seven patients performed LSG were retrieved from 7 literatures. The levels of fasting blood glucose and glycosylated hemoglobin on the postoperative 6 months were all obviously decreased as compared with the levels before operation（fasting blood glucose： MD=2.99, 95% CI 2.39-3.60, P〈0.000 01; glycosylated hemoglobin： MD=2.24, 95% CI 1.43-3.04, P〈0.000 01）, which on the postoperative 12 months were all obviously decreased as compared with the levels on the postoperative 6 months（fasting blood glucose： MD=0.56, 95% CI 0.16-0.95,P=0.006; glycosylated hemoglobin： MD=0.52, 95% CI 0.22-0.81, P=0.000 6）. The postoperative fasting blood glucose and glycosylated hemoglobin levels in patients accepted LSG showed a downward trend. Conclusions LSG on obesity with T2 MD has an obvious short-term curative effect. But its long-term efficacy still needs to be supported by large samples randomized controlled clinical research data.

关 键 词：腹腔镜袖状胃切除 肥胖 2型糖尿病 近期疗效 META分析 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]