急性冠脉综合征患者外周血CP、IMA和hs-CRP水平的变化及相关性研究  

Relationship between the level of plasma ceruloplasmin and IMA or hs-CRP in patients with coronary heart disease

作　　者：杨军[1] 周松柏[1] 罗健[1] 李芳[1] 曾欧[1] 肖婷[1] 李妍[1] 李琳[1] 褚春[2] 

机构地区：[1]南华大学附属第一医院心内科,湖南衡阳421001 [2]南华大学附属第二医院药剂科,湖南衡阳421001

出　　处：《中国医药科学》2015年第12期7-9,共3页China Medicine And Pharmacy

基　　金：国家自然科学基金(81270181;81202830)

摘　　要：目的观察稳定性冠心病和急性冠脉综合征患者外周血血清铜蓝蛋白、缺血修饰白蛋白和超敏C反应蛋白的水平。方法抽血测定27例稳定性冠心病和43例急性冠脉综合征患者及20例非冠心病对照组患者血清铜蓝蛋白、缺血修饰白蛋白和超敏C反应蛋白水平。结果急性冠脉综合征患者血清铜蓝蛋白和超敏C反应蛋白水平明显高于稳定性冠心病和及非冠心病对照组患者(P<0.05),稳定性冠心病患者血清铜蓝蛋白水平和超敏C反应蛋白水平与非冠心病对照组患者比较有升高趋势,但差异未显示出统计学意义。冠心病患者血清铜蓝蛋白水平与缺血修饰白蛋白和超敏C反应蛋白水平并无明显相关性。结论铜蓝蛋白和超敏C反应蛋白可能在冠心病的进展中扮演重要角色,在急性冠脉综合征可作为早期敏感指标;铜蓝蛋白和超敏C反应蛋白可能在冠心病的危险分层中也可作为重要指标。Objective To investigate the relationship between the level of plasma ceruloplasmin and IMA or hsCRP in patients with coronary heart disease （CHD） and acute coronary syndrome （ACS）. Methods Totally 20 cases in physical examination （control group）, then divided patients with coronary heart disease into 27 subjects with stable coronary artery disease（SCAD） group, 43 subjects with acute coronary syudrome（ACS） group. The concentrations of serum CP, ischemia-modified albumim （IMA） and hs-CRP were detected. Results The levels of serum CP and hsCRP in ACS group were obviously higher than those of SCAD group and control group （P 〈 0.05）. The levels of serum CP and hs-CRP in SAP group were significantly higher than those of control group, but it was no significant （P 〉 0.05） .The analysis of linear correlation showed that the level of CP didn＇t obviously relate with that of IMA or hs-CRP in patients with coronary heart disease （CHD）. Conclusion The results suggest that CP and hs-CRP maybe play important roles in the progression of CHD. CP and hs-CRP were early sensitive maker for ACS. The joint measurement of CP and hs- CRP may be the important maker to forecast the dangerous grade of CHD.

关 键 词：急性冠脉综合征 铜蓝蛋白 超敏C反应蛋白 缺血修饰白蛋白 危险分层 

分 类 号：R541.4[医药卫生—心血管疾病]