术前同步放化疗与单纯手术治疗局部晚期食管癌的疗效分析  

Clinical study of preoperative concurrent chemoradiation followed by surgery versus surgery alone for locally advanced esophageal carcinoma

作　　者：胡述提[1] 林涛[1] 金冰[1] 

机构地区：[1]河南省南阳市中心医院胸外科,河南南阳473009

出　　处：《中国医药科学》2015年第12期119-121,共3页China Medicine And Pharmacy

摘　　要：目的 比较术前化疗加同步半量放疗与单纯手术治疗局部晚期食管癌的疗效。方法 选取2009年1月~2010年12月间于我科行术前化疗加同步半量放疗局部晚期食管癌患者60例作为观察组,同期单纯手术的局部晚期食管癌患者60例作为对照组,观察组先给予化疗及同步半量放疗,2~4周后手术治疗,对照组直接手术治疗。对两组的手术根治切除率、围手术期死亡率、手术并发症进行比较和分析。结果 术前化疗加同步半量放疗组在手术根治切除率上明显高于对照组（P〈0.05）,两组在围手术期死亡率上无差别,在术后并发症上观察组明显低于对照组（P〈0.05）。结论 对于局部晚期食管癌,术前化疗加同步半量放疗可明显提高手术切除率,减少手术并发症。Objective To evaluate the efficacy preoperative ~/djuvant chemotherapy plus half-dose radiotherapy followed by surgery versus surgery alone for locally advanced esophageal cancer. Methods 120 patients with ocal advanced esophageal cancer from Jan 2009 to Dec 2010 were entered into this study and were divided into two groups. 60 patients treated with preoperative adjuvant chemotherapy plus half-dose radiotherapy, the surgery followed chemotherapy after 2-4 weeks; 60 patients received surgery alone. The rate of complete resection, the perioperative mortality and the frequency of complication were compared and analysised between the two groups. Results There was no significant difference in the perioperative mortality between two groups. The complete-resection-rates of experimental group were much higher than those in control group（P 〈 0.05）. Compared with the control group, the frequency of complication in experimental group were much better（P 〈 0.05）. Conclusion Preoperative adjuvant chemotherapy plus half-dose radiotherapy followed by surgery is able to significantly reduce the frequency of complication, and achieve substaintially complete-resection-rate during operation.

关 键 词：局部晚期食管癌 食管癌切除术 新辅助化疗 术前半量放疗 

分 类 号：R655.4[医药卫生—外科学]