血浆脑钠肽、肌钙蛋白T水平在急性冠脉综合征危险分层的相关性研究  

Study on the correlation between the serum brain natriuretic peptide、cardiac troponin T and the risk stratification of coronary artery lesion

作　　者：陈容梅 陈琬琼 黎志明 欧阳翠华 叶显明 李巧汶[2] 

机构地区：[1]广东省阳山县人民医院心血管内科,广东阳山513100 [2]广东省清远市人民医院,广东清远511500

出　　处：《中国医药科学》2015年第12期127-129,共3页China Medicine And Pharmacy

摘　　要：目的 通过分析不同Gensini积分的急性冠脉综合征患者血清脑钠肽（BNP）和心肌钙蛋白T（e Tn T）水平,探讨BNP和e Tn T浓度变化与ACS临床危险分层的相关性。方法 研究纳入120例2013年6月~2014年6月入院接受冠状动脉造影的ACS患者,所有患者入院期间完成病史、血脂、血糖、血常规、血压、肾功能等常规临床资料收集,并检测血清BNP和e Tn T浓度;按ACS冠脉病变程度Gensini积分不同分为三组,分别为Gensini积分〉40分组,Gensini积分20~40分组和Gensini积分〈20分组,比较三组血清BNP和e Tn T浓度变化差异。结果 Gensini积分〈20分组血清BNP水平显著低于Gensini积分〉40分组（P〈0.05）,且与Gensini积分20~40分组,差异无统计学意义（P〉0.05）,Gensini积分20~40分组血清BNP水平显著低于Gensini积分〉40分组（P〈0.05）;Gensini积分〉40分组血清e Tn T浓度最高,其次为Gensini积分20~40分组和Gensini积分〈20分组,各组间均有显著性差异（P〈0.05）;血清BNP和e Tn T浓度与Gensini积分呈显著正相关（r=0.297,r=0.361,P〈0.05）。结论 ACS患者血清BNP和e Tn T浓度对疾病危险分层有一定相关性,对临床诊断和治疗及预后有重要参考价值。Objective To explore the correlation between the serum brain natriuretic peptide （BNP）,cardiac troponin T （eTnT） and the risk stratification of coronary artery lesion through analysis the level of BNP and eTnT of ACS patients with different Gensini score. Methods 120 patients with ACS in our hospital from June 2013 to June 2014 were accepted coronary angiography, and the medical history,blood lipid,blood sugar,blood routine, blood pressure, renal function and other conventional clinical datas of all patients were collected during the period of admission, the serum BNP and eTnT of all patients were tested, all patients were divided into three groups according to the Gensini score of the degree of coronary artery lesions, there were Gensini score 〉 40 scores group and Gensini score 20-40 scores group and Gensini score 〈 20 scores group Respectively,and the difference of serum BNP and eTnT in three groups were compared. Results The serum BNP in Gensini score 〈 20 scores group was significant lower than C, ensini score 〉 40 scores group（P 〈 0.05） and had no significant difference with Gensini score 20-40 scores group（P 〉0.05）; The serum BNP in Gensini score 20-40 scores group was significant lower than Gensini score 〉 40 scores group（P 〈 0.05）; The serum eTnT in Gensini score 〉 40 scores group was highest, and the serum eTnT in Gensini score 20-40 scores group and Gensini score 〈 20 scores group were followed,there was significant difference between each group; There was a significant positive correlation between the serum BNP, eTnT and Gensini score. Conclusion There has positive correlation between the serum BNP, cTnT of ACS patients and the risk stratification of coronary artery lesion,it has important reference value for clinical diagnosis and treatment.

关 键 词：急性冠综合征 脑钠肽 心肌钙蛋白T 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]