消白胶囊质量标准研究  

Study on the Quality Standard for Xiaobai Capsules

作　　者：梁佳龙[1,2] 杨一帆[3] 张东旭[1] 景慧雯[2] 王玉琨[1] 

机构地区：[1]第四军医大学药学系,西安710032 [2]解放军第十一医院 [3]第四军医大学医学统计学教研室

出　　处：《中国药师》2015年第8期1309-1312,共4页China Pharmacist

摘　　要：目的:建立消白胶囊的质量标准。方法:采用薄层色谱法对菟丝子、当归、白芍进行定性鉴别;建立补骨脂素、异补骨脂素的高效液相色谱含量测定方法。结果:定性鉴别阴性无干扰,分离度高;补骨脂素线性范围为1.082~108.200μg·ml^-1(r=0.999 8),平均回收率为99.82%,RSD=1.16%。异补骨脂素线性范围为0.818~81.800μg·ml^-1(r=0.999 7),平均回收率为99.85%,RSD=1.81%。结论:所建立的质量标准方法可行,可用于消白胶囊的质量控制。To establish the quality standard for Xiaobai capsules. Methods： Paeoniae Radix Alba and Angelicae Sinensis Radix were identified by TLC. The contents of psoralen and isopsoralen were determined by HPLC. Results：The qualitative i-dentification was with high resolution and without interference from the negative substances. The linear range of psoralen was 1. 082-108. 200 μg·ml-1 . The average recovery was 99. 82% with RSD of 1. 16%. The linear range of isopsoralen was 0. 818-81. 800μg· ml-1 . The average recovery was 99. 85% with RSD of 1. 81%. Conclusion：The method can be used in the quality control of Xiaobai capsules.

关 键 词：消白胶囊 质量标准 薄层色谱法 高效液相色谱法 

分 类 号：TQ460.72[医药卫生—药物分析学]