肝素联合低分子肝素预防动静脉内瘘术后早期血栓形成  

Preventive Effect of Heparin Combined with Low Molecular Heparin on Primary Thrombosis in Arteriovenous Fistula Patients

作　　者：范星[1] 林利[2] 任星峰[1] 彭隽[1] 兰天飚[1] 

机构地区：[1]广州军区武汉总医院肾内科,武汉430070 [2]广州军区武汉总医院超声影像科,武汉430070

出　　处：《中国药师》2015年第8期1328-1330,共3页China Pharmacist

摘　　要：目的:研究肝素联合低分子肝素对预防动静脉内瘘(AVF)术后早期血栓形成的影响。方法:采用前瞻性研究方法,将299例行AVF术的患者随机分为两组,对照组患者术后给予低分子肝素5 000 IU皮下注射qd×7 d;观察组术中在游离动脉端与静脉端分别推注1 500 u肝素钠,术后给予低分子肝素5 000 IU皮下注射qd×7 d。观察两组患者术后1周和4周AVF血栓形成率及药品不良反应(ADR)发生情况。结果:术后1周,对照组和观察组的AVF血栓形成率分别为3.4%和0;术后4周分别为4.8%和0.67%,观察组均明显低于对照组(P<0.05)。两组ADR发生率差异无统计学意义(P>0.05),未发生严重不良反应。结论:肝素联合低分子肝素可降低AVF术后早期血栓形成率,提高手术成功率,安全性较好。To evaluate the efficacy of heparin combined with low molecular heparin against early thrombosis in chronic patients after native arteriovenous fistula （ AVF） . Methods： A total of 299 patients were enrolled in the study from January 2012 to December 2014 and randomly divided into two groups. The control group received 5000IU low molecular heparin after the operation for 7 days and the trial group received 3 000u heparin additionally through free arterial end and venous terminal during the operation. The thrombosis formation rate and adverse drug reactions （ ADR ） of one week and 4 weeks after the operation were observed in the two groups. Results：One week after the operation, the thrombosis formation rate in the control group and the trial group was 3. 4% and 0, respectively, and four week after the operation, that was 4. 8% and 0. 67%, respectively. The incidence of ADR showed no statistical-ly difference between the two groups （P〉0. 05）, and no severe ADR appeared in both groups. Conclusion：Heparin combined with low molecular heparin may be more effective and safer in the prevention of primary thrombosis in the patients after AVF.

关 键 词：肝素 低分子肝素 慢性肾功能衰竭 动静脉内瘘 血栓形成 

分 类 号：R973.2[医药卫生—药品]