肾上腺素联合布地奈德雾化吸入治疗儿童急性喉炎疗效观察  

Effects of Atomization Inhalation of Adrenaline Combined with Budesonide in the Treatment of Children with Acute Laryngitis

作　　者：姚淑英[1] 徐英[1] 

机构地区：[1]嵊州市妇幼保健院儿科,浙江嵊州312400

出　　处：《中国药师》2015年第8期1357-1359,共3页China Pharmacist

摘　　要：目的:对比肾上腺素联合布地奈德雾化吸入与地塞米松雾化吸入治疗儿童急性喉炎的临床疗效及安全性。方法:68例急性喉炎患儿随机分成两组,均给予常规综合治疗,在此基础上,对照组30例予地塞米松雾化吸入;观察组38例予肾上腺素联合布地奈德雾化吸入。观察两组患儿治疗12,24,72 h临床效果、临床症状体征消失时间及药品不良反应。结果:观察组患儿治疗12,24,72 h后临床效果均显著优于对照组(P<0.05);治疗72 h,观察组治愈率为71.05%,明显高于对照组的56.67%(P<0.05)。观察组临床症状体征消失时间均显著早于对照组(P<0.05);两组患儿均未见明显药品不良反应。结论:肾上腺素联合布地奈德雾化吸入治疗儿童急性喉炎临床效果优于地塞米松雾化吸入,能迅速改善患儿临床症状体征,且安全性好,值得临床推广应用。To compare the clinical efficacy and safety of atomization inhalation of epinephrine combined with budes-onide and dexamethasone in the treatment of children with acute laryngitis. Methods：Totally 68 cases of children with acute laryngitis were randomly divided into two groups. The two groups were given the conventional therapy, and 30 cases in the control group were giv-en dexamethasone inhalation additionally, and the treatment group was given epinephrine combined with budesonide inhalation addition-ally. The clinical effect in 12, 24 and 72h, clinical symptom disappearance time and adverse reactions in the two groups were ob-served. Results：The clinical effect of the treatment group in 12, 24 and 72h was better than that in the control group. 72h after the treatment, 17 cases in the control group were cured, and the curative rate was 56. 67%, while 27 cases in the treatment group were cured with the curative rate of 71. 05%. The disappearance time of dyspnea and stridor, barking cough, hoarseness and the other clini-cal symptoms in the treatment group was significantly shorter than that in the control group, and the difference was statistically signifi-cant （P〈0. 05）. The two groups had no obvious adverse reaction. Conclusion：The clinical effect of the combination of epinephrine and budesonide inhalation in the treatment of children with acute laryngitis is better than that of dexamethasone inhalation, and the combination is safe and effective, which is worthy of clinical application.

关 键 词：肾上腺素 布地奈德 地塞米松 雾化吸入 儿童急性喉炎 

分 类 号：R971.93[医药卫生—药品]