阴炎净凝胶对大鼠细菌性阴道炎的药效学研究  

Pharmacodynamics Studies of Yinyanjing Gel in the Treatement of Bacterial Vaginitis in Rats

作　　者：李子珊 王蓉蓉 李瑞莲 吴雅莉[2] 

机构地区：[1]湖南省食品药品检验研究院,长沙410001 [2]湖南省妇幼保健院

出　　处：《中国药师》2015年第8期1389-1391,共3页China Pharmacist

基　　金：湖南省中医药管理局重点项目(编号:201207)

摘　　要：目的:观察阴炎净凝胶的抑菌、抗炎和止痒作用。方法:采用倍比稀释法测定本品的体外抑菌效果;采用大鼠造模法观察本品对细菌性阴道炎的治疗作用;采用豚鼠止痒实验观察本品的止痒作用。结果:阴炎净凝胶对金黄色葡萄球菌的MIC为47.39 mg·ml-1;对大肠埃希菌的MIC为189.59 mg·ml-1;对细菌性阴道炎具有明显的治疗作用;对磷酸组织胺所致豚鼠具有明显止痒作用。结论:阴炎净凝胶具有抑菌、消炎和止痒作用。To study the bacteriostat, anti-inflammatory and relieving itching effects of Yinyanjing gel. Methods： A double dilution method was used to detect the in vitro bacteriostat effect of Yinyanjing gel. The therapeutic effects of Yinyanjing gel on bacterial vaginitis were observed in rats. The antipruritic effect of Yinyanjing gel was observed in guinea pigs. Results：MIC for Staphy-lococcus aureus was 47. 39 mg·ml-1 , and that for Escherichia coli was 189. 59 mg·ml-1 . The therapeutic effects of Yinyanjing gel on bacterial vaginitis were significant. Yinyanjing gel showed notable antipruritic effect on the itching induced by histamine phosphate in guinea pigs. Conclusion：Yinyanjing gel exhibits significant effects of bactriostasis,anti-inflammation and relieving itching.

关 键 词：阴炎净凝胶 大鼠 细菌性阴道炎 

分 类 号：R285.5[医药卫生—中药学]