柴葛清热颗粒抗炎镇痛解热作用研究  

Anti-inflammatory,Analgesia and Antipyretic Effects of Chaige Qingre Granules

作　　者：曾俊芬[1] 宋金春[1] 鲁建武[1] 

机构地区：[1]武汉大学人民医院药学部,武汉430060

出　　处：《中国药师》2015年第8期1407-1409,共3页China Pharmacist

摘　　要：目的:研究柴葛清热颗粒的抗炎、镇痛、解热作用。方法:采用昆明种小鼠,以二甲苯致小鼠耳廓肿胀法对柴葛清热颗粒进行抗炎作用评价;以醋酸致小鼠扭体法对柴葛清热颗粒进行镇痛作用评价;采用酵母对Wistar大鼠致热法测定柴葛清热颗粒的解热作用。结果:柴葛清热颗粒对小鼠耳廓肿胀有显著抑制作用,高剂量时其抑制率为46.3%;柴葛清热颗粒中、高剂量组对小鼠疼痛有显著缓解作用,抑制率分别为51.1%,61.8%;大鼠体温上升1 h,柴葛清热颗粒低中高剂量组即对其体温有显著降低作用,高剂量组对发热大鼠降温达0.56℃。结论:柴葛清热颗粒能抑制小鼠耳廓肿胀,缓解小鼠疼痛,降低高热大鼠体温。To investigate the anti-inflammatory, analgesia and antipyretic effects of Chaige Qingre granules. Meth-ods：Kunming mice were used to make auricle swelling model by dimthylphenanthrene, and the auricle swelling degree was measured to test the anti-inflammatory effect of Chaige Qingre granules. Mice were used to make pain models by acetic acid, and the body twis-ting of the mice was counted to observe the analgesia effect of the granules. The fever model in rats was induced by yeast, and the body temperature of the rats was measured to investigate the antipyretic effects of the granules. Results：Chaige Qingre granules could relieve the auricle swelling degree significantly, and the inhibition rate was 46. 3% in the high dose group. High and middle dose groups could reduce the body twisting frequency with the inhibition rate of 51. 1% and 61. 8%, respectively. Every Chaige Qingre granules group could lower the body temperature after one hour of the administration, and the temperature could be reduced 0. 56 degrees Celsius in the high dose group. Conclusion：Chaige Qingre granules can effectively inhibit auricle swelling degree, relieve pain and reduce heat.

关 键 词：柴葛清热颗粒 抗炎 镇痛 解热 

分 类 号：R285.5[医药卫生—中药学]