复方鱼腥草片中山银花检查方法的建立  

Determination of Lonicerae Flos in Compound Yuxingcao Tablets

作　　者：郭巧技[1,2] 苏畅[1,2] 宋茜[1] 罗婧[1] 王珏[1,2] 王淑红[1,2] 王铁杰[1,2] 

机构地区：[1]深圳市药品检验所,广州深圳518057 [2]深圳岭南药材资源开发与应用工程实验室

出　　处：《中国药师》2015年第8期1416-1419,共4页China Pharmacist

摘　　要：目的:对复方鱼腥草片中金银花的质量进行研究。方法:建立以灰毡毛忍冬皂苷甲、灰毡毛忍冬皂苷乙及川续断皂苷乙为对照的HPLC-ELSD和LC-MS/MS法检查山银花的方法。结果:HPLC-ELSD法适用于复方鱼腥草片中山银花的检查,并采用LC-MS/MS法对结果进行验证,能鉴别出样品中所用正伪品金银花药材。结论:上述2种方法均可用于控制复方鱼腥草片中金银花的质量。To study the quality of Lonicerae iaponicae flos in compound Yuxingcao tablets. Methods： HPLC-ELSD and LC-MS/MS were used to determine Lonicerae flos using macranthoidin A, macranthoside B and dipsacoside B as the control. Re-sults：HPLC-ELSD was suitable for the detection of Lonicerae flos in compound Yuxingcao tablets. LC-MS/MS was used to verify the results, which could identify the certified or counterfeit Lonicerae iaponicae flos in the samples. Conclusion：The two methods can be used to control the quality of Lonicerae iaponicae flos in compound Yuxingcao tablets.

关 键 词：复方鱼腥草片 山银花 灰毡毛忍冬皂苷甲 灰毡毛忍冬皂苷乙 川续断皂苷乙 高效液相色谱法 LC-MS/MS法 

分 类 号：R282.5[医药卫生—中药学]