Use of Platelet Indices for Determining Illness Severity and Predicting Prognosis in Critically III Patients  

作　　者：Sheng Zhang Yun-Liang Cui Meng-Yuan Diao Deng-Chang Chen Zhao-Fen Lin 

机构地区：[1]Department of Emergency Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China [2]Department of Critical Care Medicine, Jinan Military General Hospital, Jinan, Shandong 250031, China [3]Department of Outpatient, Naval Logistics Branch of Hangzhou Sanatorium, Nanjing Military Area Command,Hangzhou, Zhejiang 310002, China

出　　处：《Chinese Medical Journal》2015年第15期2012-2018,共7页中华医学杂志（英文版）

摘　　要：Background：Decreased platelet （PLT） count is one of the independent risk factors for mortality in intensive care unit （ICU） patients.This study was to investigate the relationship between PLT indices and illness severity and their performances in predicting hospital mortality.Methods：Adult patients who admitted to ICU of Changzheng Hospital from January 2011 to September 2012 and met inclusion criteria were included in this study.Univariate analysis was used to identify potential independent risk factors for mortality.Multiple logistic regression analysis was used to calculate adjusted odds ratio for mortality in patients with normal or abnormal PLT indices.The relationship between PLT indices and illness severity were assessed by the Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） scores or sequential organ failure assessment （SOFA） scores in patients with normal and abnormal PLT indices.The performances of PLT indices in predicting mortality were assessed by receiver operating curves and diagnostic parameters.The survival curves between patients with normal and abnormal PLT indices were compared using Kaplan-Meier method.Results：From January 2011 to September 2012,261 of 361 patients （204 survivors and 57 nonsurvivors） met the inclusion criteria.After adjustment for clinical variables,PLT count 〈 100 × 10^12/L （P =0.011）,plateletcrit （PCT） 〈0.108 （P =0.002）,mean platelet volume （MPV） 〉11.3 fL （P =0.023） and platelet distribution width （PDW） percentage 〉17% （P =0.009） were identified as independent risk factors for mortality.The APACHE Ⅱ and SOFA scores were 14.0 （9.0-20.0） and 7.0 （5.0-10.5） in the ＂low PLT＂ tertile,13.0 （8.0-16.0） and 7.0 （4.0-11.0） in the ＂low PCT＂ tertile,14.0 （9.3-19.0） and 7.0 （4.0-9.8） in the ＂high MPV＂ tertile,14.0 （10.5-20.0） and 7.0 （5.0-11.0） in the ＂high PDW＂ tertile,all of which were higher than those in patients with normal indices.Patients with decreasedBackground：Decreased platelet （PLT） count is one of the independent risk factors for mortality in intensive care unit （ICU） patients.This study was to investigate the relationship between PLT indices and illness severity and their performances in predicting hospital mortality.Methods：Adult patients who admitted to ICU of Changzheng Hospital from January 2011 to September 2012 and met inclusion criteria were included in this study.Univariate analysis was used to identify potential independent risk factors for mortality.Multiple logistic regression analysis was used to calculate adjusted odds ratio for mortality in patients with normal or abnormal PLT indices.The relationship between PLT indices and illness severity were assessed by the Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） scores or sequential organ failure assessment （SOFA） scores in patients with normal and abnormal PLT indices.The performances of PLT indices in predicting mortality were assessed by receiver operating curves and diagnostic parameters.The survival curves between patients with normal and abnormal PLT indices were compared using Kaplan-Meier method.Results：From January 2011 to September 2012,261 of 361 patients （204 survivors and 57 nonsurvivors） met the inclusion criteria.After adjustment for clinical variables,PLT count 〈 100 × 10^12/L （P =0.011）,plateletcrit （PCT） 〈0.108 （P =0.002）,mean platelet volume （MPV） 〉11.3 fL （P =0.023） and platelet distribution width （PDW） percentage 〉17% （P =0.009） were identified as independent risk factors for mortality.The APACHE Ⅱ and SOFA scores were 14.0 （9.0-20.0） and 7.0 （5.0-10.5） in the ＂low PLT＂ tertile,13.0 （8.0-16.0） and 7.0 （4.0-11.0） in the ＂low PCT＂ tertile,14.0 （9.3-19.0） and 7.0 （4.0-9.8） in the ＂high MPV＂ tertile,14.0 （10.5-20.0） and 7.0 （5.0-11.0） in the ＂high PDW＂ tertile,all of which were higher than those in patients with normal indices.Patients with decreased

关 键 词：Mean Platelet Volume Platelet Count Platelet Distribution Width Platelet Indices PLATELETCRIT 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术] X823[环境科学与工程—环境工程]