带状疱疹患者血浆同型半胱氨酸水平的检测  

Level of plasma homocysteine in patients with herpes zoster

作　　者：李胜华[1] 谭宇飞 曹庆科[1] 殷文浩[1] 邹洪兴[2] 姚明[1] 

机构地区：[1]浙江省嘉兴市第一医院皮肤科,314000 [2]浙江省嘉兴市第一医院临床实验室,314000

出　　处：《中华全科医师杂志》2015年第8期626-628,共3页Chinese Journal of General Practitioners

基　　金：浙江省中西医结合疼痛医学创新学科建设计划（2012-XK-22）;浙江省卫生高层次创新人才培养工程项目（2012-RC-22）

摘　　要：对101例带状疱疹患者（观察组）治疗前和100例健康体检者（对照组）的血浆同型半胱氨酸（Hcy）、叶酸、维生素B12水平及观察组治疗后Hey水平进行测定.治疗前观察组血浆Hcy水平明显高于对照组[（15.7±6.1）与（7.6±2.2）μmol/L,P＜0.01];两组维生素B12和叶酸水平比较,差异均无统计学意义（P＞0.05）.观察组中高Hcy率及Hcy水平在不同年龄、皮损范围及疼痛程度者间存在差异（P＜0.05）;而在不同性别、皮损部位者问差异均无统计学意义（P＞0.05）.正规治疗1个月后,血Hcy水平较治疗前均明显下降（P＜0.01）.提示,带状疱疹患者具有较高的Hcy水平,与年龄、皮损范围、疼痛程度相关,与性别、发病部位及体内叶酸、维生素B12水平无关.The plasma levels of homocysteine （Hcy）,vitamin B12 and folic acid were measured in a total of 101 patients with herpes zoster （observation group） before treatment and 100 healthy controls （control group）.And the plasma level of Hcy was also measured in observation group after treatment.There was a significant increase of Hcy level in observation group versus control group （P ＜0.01）.And the levels of VitB12 and folic acid did not fluctuate （P ＞ 0.05）.The occurrence rate of hyperhomocysteinemia and the level of Hcy differed in age group,onset site and pain severity （P ＜ 0.05）.No significant differences existed between gender or onset site （P ＞ 0.05）.The level of Hcy significantly decreased after treatment versus before treatment （P ＜0.01）.Plasma Hcy significantly increased in patients with herpes zoster.And it was correlated with age,lesion extent and pain severity.However,there was no correlation with gender,onset site or levels of vitamin B12 and folic acid.

关 键 词：疱疹 带状 同型半胱氨酸 维生素B12 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]