来曲唑促排卵治疗无排卵性不孕的临床效果分析  

Clinical analyses of letrozole treatment in stimulating ovulation for anovulatory infertile women

作　　者：宋堃玲[1] 邢玉鉴 

机构地区：[1]海南省三亚市人民医院妇产科,570000

出　　处：《中华全科医师杂志》2015年第8期629-631,共3页Chinese Journal of General Practitioners

摘　　要：对130例无排卵性不孕患者于月经第5天分别予来曲唑2.5 mg（LE1组,45例）和5.0 mg（LE2组,30例）、枸橼酸氯米芬50 mg（CC1组,35例）和100 mg（CC2组,20例）每天1次口服治疗,共5d,第10天行B超监测,在卵泡成熟时给予hCG 8 000 - 10 000 U注射.LE1组与CC1组临床妊娠率（33％与14％）、排卵率（78％与54％）、注射hCG日雌二醇（E2）水平[（774.2±126.0）与（963.7±108.3）pmol/L]、子宫内膜厚度[（9.6±1.3）与（5.9±1.1）mm]、成熟卵泡个数[（1.20±0.38）与（2.28±0.88）个]比较,差异有统计学意义（x2值分别为4.00和4.60,均P＜0.05,t值分别3.98、6.20和4.76,均P＜0.01）;LE1与LE2组、CC1与CC2组上述指标比较,差异均无统计学意义.共妊娠36例,足月分娩26例,新生儿健康,早期流产2例,早产2例,6例正常妊娠中;卵巢过度刺激综合征的发生率低且程度轻.A total of 130 anvolatory infertile outpatients were divided randomly into 4 groups of LE1 （letrozole 2.5 mg,n =45）,LE2 （letrozole 5 mg,n =30）,CC1 （clomiphene citrate 50 mg,n =35） and CC2 （clomiphene citrate 100 mg,n =20）.The treatments started at day 5 of menstruation and lasted for 5 days.The size and number of ovarian follicles and thickness of endometrium of all 4 groups were measured starting from day 10 of menstruation.8 000-10 000 units of human chorionic gonadotropin （hCG） was injected when ovary follicles were mature.And blood estradiol （E2） was measured at the same day.Ovulation,pregnancy and adverse reaction were also monitored.The pregnancy rate was 33% （n =15） in group LE1 and 14% （n =5） in group CC1 with significant statistical difference （x2 =4.00,P 〈 0.05）.And there were 43 successful ovulation periods in 55 periods with an ovulation rate of 78% in group LE1;28 successful ovulation periods in 52 periods with an ovulation rate of 54% in group CC with significant statistical difference （X2 =4.60,P 〈0.05）.E2 level （pmol/L） in the day of hCG injection in group LE1 was （774.2 ± 126.0） pmol/L and in group CC1 （963.7 ± 108.3） pmol/L,t =3.98 with significant difference （P 〈 0.01）.The number of follicle in group LE1 was 1.20 ± 0.38;CC1 2.28 ± 0.88,t =4.76 with significant difference （P 〈0.01）.The thickness of endometrium in the day of hCG in LE1 was （9.6 ± 1.3） mm;CC1 （5.9 ± 1.1） mm,t =6.20 with significant difference （P 〈 0.01）.No significant statistical differences existed between LE1 and LE2,CC1 and CC2 in pregnancy rate,successful ovulation,number of mature follicles,E2 level and thickness of endometrium at the day of hCG injection.The outcomes of 36 pregnancies were 32 full-term deliveries with neonatal health,2 early abortions and 2 prematures.Mild ovarian hyperstimulation syndrome （OHSS） had a low occurrence rate.

关 键 词：不育 女(雌)性 排卵诱导 

分 类 号：R711.6[医药卫生—妇产科学]