膜叶槌果藤水提物镇痛抗炎作用的实验研究  

Experimental Study of Anti-inflammatory and Analgesic Effects of Capparis Membranacea Aqueous Extract

作　　者：冯洁颖[1] 戴卫波[1] 吴凤荣[1] 

机构地区：[1]中山市中医院,广东中山528400

出　　处：《中国执业药师》2015年第8期24-27,共4页China Licensed Pharmacist

基　　金：中山市卫生局医学科研立项(2013J088)

摘　　要：目的 :研究膜叶槌果藤水提物镇痛抗炎作用。方法:小鼠分别连续灌胃给予膜叶槌果藤水提物高、中、低剂量(10.88,5.44,2.72 g/kg)7 d,采用扭体法、福尔马林致痛模型、二甲苯致耳肿胀模型及腹腔毛细血管通透性实验,观察其镇痛抗炎作用。结果:膜叶槌果藤水提物可显著抑制冰醋酸引起的小鼠扭体反应次数(P<0.01);对福尔马林致小鼠疼痛舔足第Ⅰ,Ⅱ时相累积时间均有显著减少(P<0.05或P<0.01);对二甲苯致小鼠耳肿胀有显著的抑制作用(P<0.05或P<0.01);对冰醋酸引起的毛细血管通透性也有显著的抑制作用(P<0.01)。结论:膜叶槌果藤水提物具有显著的镇痛抗炎作用。Objective：To study the analgesic and anti-inflammatory effects of capparis membranacea water extracts. Methods ：Capparis membranacea aqueous extracts at high, middle and low doses （10.88, 5.44, 2.72 g/kg） were given respectively to mice by intragastric administration for 7 days. The analgesic and anti-inflammatory effects were observed through writhing response, formalin induced pain model, xylene induced ear swelling model and celiac capillary permeability test. Results：Capparis membranacea water extract can obviously inhibit the times of writhing response in mice induced by glacial acetic acid （P 〈 0.01 ）, the I, II phase accumulation time of mouse foot licking of formalin induced pain in mice reduced significantly （P 〈 0.05 or P 〈 0.01 ）, xylene induced ear swelling in mice and capillary permeability induced by acetic acid were significantly inhibited （P 〈 0.05 or P 〈 0.01 and P 〈 0.01 ）. Conclusion： Cappads membranacea water extract has obvious analgesic and anti-inflammatory effects.

关 键 词：膜叶槌果藤 镇痛 抗炎 

分 类 号：R285.5[医药卫生—中药学]