Insights into the function of tegument proteins from the varicella zoster virus  

作　　者：WANG Wei CHENG Tong ZHU Hua XIA NingShao 

机构地区：[1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science, Xiamen University [2]Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University

出　　处：《Science China(Life Sciences)》2015年第8期739-749,共11页中国科学（生命科学英文版）

基　　金：supported by the Fujian Technological Innovation Platform Fund(2014Y2101);the Xiamen City Municipal Platform Fund(3502Z201410045,3502Z20131001)

摘　　要：Chickenpox(varicella) is caused by primary infection with varicella zoster virus(VZV), which can establish long-term latency in the host ganglion. Once reactivated, the virus can cause shingles(zoster) in the host. VZV has a typical herpesvirus virion structure consisting of an inner DNA core, a capsid, a tegument, and an outer envelope. The tegument is an amorphous layer enclosed between the nucleocapsid and the envelope, which contains a variety of proteins. However, the types and functions of VZV tegument proteins have not yet been completely determined. In this review, we describe the current knowledge on the multiple roles played by VZV tegument proteins during viral infection. Moreover, we discuss the VZV tegument protein-protein interactions and their impact on viral tissue tropism in SCID-hu mice. This will help us develop a better understanding of how the tegument proteins aid viral DNA replication, evasion of host immune response, and pathogenesis.Chickenpox （varicella） is caused by primary infection with varicella zoster virus （VZV）, which can establish long-term latency in the host ganglion. Once reactivated, the virus can cause shingles （zoster） in the host. VZV has a typical herpesvirus virion structure consisting of an inner DNA core, a capsid, a tegument, and an outer envelope. The tegument is an amorphous layer enclosed between the nucleocapsid and the envelope, which contains a variety of proteins. However, the types and functions of VZV tegument proteins have not yet been completely determined. In this review, we describe the current knowledge on the multiple roles played by VZV tegument proteins during viral infection. Moreover, we discuss the VZV tegument protein-protein interactions and their impact on viral tissue tropism in SCID-hu mice. This will help us develop a better understanding of how the tegument proteins aid viral DNA replication, evasion of host immune response, and pathogenesis.

关 键 词：varicella zoster virus VZV TEGUMENT 

分 类 号：R373[医药卫生—病原生物学]