红细胞分布宽度与频发室性期前收缩患者左心室肥厚的相关性分析  

The relationship between the red blood cell distribution width and left ventricular hypertrophy in patients with frequent premature ventricular contraction

作　　者：刘建峰 罗鸿宇[2] 郝鹏[3] 朱玮玮[2] 王钢[2] 李敬[2] 华琦[2] 

机构地区：[1]北京市利康医院住院部,北京102609 [2]首都医科大学宣武医院心脏科,北京100053 [3]首都医科大学附属北京安贞医院急诊科,北京100029

出　　处：《中国医药导报》2015年第23期4-7,16,共5页China Medical Herald

基　　金：国家高科技发展计划(863计划)项目(2012AA02A516)

摘　　要：目的观察红细胞分布宽度（RDW）与频发室性期前收缩（FPVC）患者左心室肥厚（LVH）的相关性,探讨可能影响FPVC发生LVH的因素。方法连续入选2014年3月-2015年3月于首都医科大学宣武医院心脏科门诊122例明确诊断为FPVC患者,平均年龄（57.00±13.16）岁。所有患者均检测生化指标及血常规指标,行超声心动图检查并计算左室心肌质量指数（LVMI）。定义LVH为：女性患者LVMI≥110 g/m^2,男性患者LVMI≥135 g/m^2。根据LVMI将患者分为FPVC合并LVH组（观察组,n=66）与FPVC无LVH组（对照组,n=56）。应用多元线性回归及Logistic回归分析RDW与FPVC患者LVH的相关性。结果两组间性别、红细胞计数（RBC）、血红蛋白（Hb）、空腹血糖（FBG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及合并疾病情况差异均无统计学意义（P〉0.05）;观察组年龄、室早负荷（PVC burden）及RDW水平均高于对照组,差异有统计学意义（P〈0.05）。Pearson相关分析显示,RDW与LVMI呈正相关（r=0.259,P=0.004）。多元线性回归分析结果显示,年龄、RDW、室早负荷与LVMI呈线性正相关（P〈0.05）。在校正了混杂因素后Logistic回归分析显示,RDW仍是PVC合并LVH的独立预测因素（OR=0.455,95%CI：0.224-0.922,P=0.029）。结论FPVC患者的RDW与LVMI呈正相关,RDW可能是FPVC患者发生LVH的预测因素。Objective To investigate the relationship between the red blood cell distribution width（RDW） and left ventricular hypertrophy（LVH）, study the predictors of LVH in patients with frequent premature ventricular contraction（FPVC）. Methods 122 patients with FPVC from March 2014 to March 2015 were selected from Department of Cardiology, Xuanwu Hospital, Capital Medical University, average age of（57.00±13.16） years. The biochemical indexes, blood routine index and echocardiography were detected, the left ventricular myocardial mass index（LVMI） was calculated.Definition of left ventricular hypertrophy： women with LVMI≥110 g/m^2 or men with LVMI≥135 g/m^2. All patients were divided into 2 groups according to the LVMI： observation group（FPVC combined with LVH, n = 66） and control group（only FPVC, n = 56）. The correlation between RDW and LVH of patients with FPVC was analyzed by multivariate linear regression and Logistic regression. Results There were no significant differences in sex, red blood cell count（RBC）,hemoglobin（Hb）, fasting blood glucose（FBG）, triglyceride（TG）, total cholesterol（TC）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C） and comorbidities between the two groups（P〉0.05）. The levels of age, RDW and PVC burden in observation group were significantly higher than those in control group（P〈0.05）. Pearson correlation analysis showed that RDW was significantly correlated with LVMI（r = 0.259, P = 0.004）. Multivariate linear regression analysis showed, age, RDW, PVC burden and LVMI had linear positve correlation. After correction for confounding factors, Logistic regression showed that RDW was an independent predictor of LVH in patients with FPVC（OR = 0.455, 95%CI： 0.224-0.922, P = 0.029）. Conclusion RDW and LVMI is positively correlated in patients with FPVC, and RDW is an independent predictor for FPVC with LVH.

关 键 词：频发室性期前收缩 红细胞分布宽度 左心室肥厚 左室心肌质量指数 

分 类 号：R541.75[医药卫生—心血管疾病]