两性霉素B治疗艾滋病合并真菌感染的疗效及不良反应评价  

Therapeutic Efficacy and ADR Evaluation of Amphotericin B in the Treatment of AIDS Complicating with Fungal Infections

作　　者：洪仲思[1] 陈奕伸[1] 田琳[1] 梁嘉碧[1] 郑晓滨[1] 

机构地区：[1]中山大学附属第五医院,广东珠海519000

出　　处：《中国药房》2015年第23期3238-3240,共3页China Pharmacy

基　　金：广东省中医药局科研课题(No.20131047)

摘　　要：目的:评价两性霉素B治疗艾滋病合并真菌感染的疗效及药品不良反应。方法:收集我院应用两性霉素B治疗艾滋病合并真菌感染的病例,评价总体疗效、患者致病菌分布和用药后清除率及不良反应。结果:共纳入患者89例,其中显效45例,好转32例,无效12例,有效率为86.5%。有76例找到或培养出真菌,其中64株被清除,12株未清除,总体清除率为84.2%。出现不良反应41例(46.1%),其中2例(2.2%)因严重肾功能损害更换用药,其余患者对症处理后均不影响治疗疗程。结论:两性霉素B治疗艾滋病合并真菌感染疗效确切,药品不良反应在可控制范围内。OBJECTIVE：To evaluate therapeutic efficacy and ADR of amphotericin B in the treatment of AIDS combined with fungal infections retrospectively. METHODS：The cases of amphotericin B in the treatment of AIDS combined with fungal infections were collected our hospital. Total therapeutic efficacy,distribution of pathogenic bacteria,clearance rate and ADR were evaluated. RESULTS：89 patients were involved totally,among which 45 cases were marked effect,32 cases improved and 12 cases failed,with effective rate of 86.5%. The fungus were found or cultured in 76 cases,among which 64 strains were cleared,but12 strains were not,with total clearance rate of 84.2%. There were 41 ADR cases（46.1%）,while all completed the treatment except 2 developing severe renal failure（2.2%）. CONCLUSIONS：Domestic amphotericin B could effectively treat AIDS complicating with fungal infections,and the ADRs were acceptable.

关 键 词：艾滋病 真菌感染 两性霉素B 疗效 不良反应 

分 类 号：R512.91[医药卫生—内科学] R978.5[医药卫生—临床医学]