替诺福韦酯治疗多重耐药慢性乙型肝炎的回顾性分析  

Retrospective Analysis of Tenofovir Disoproxil Fumarate in the Treatment of Multi-drug Resistant Chronic Hepatitis B

作　　者：冯淑焕[1] 唐克诚[1] 李谦[1] 

机构地区：[1]天津市第二人民医院ICU,天津300192

出　　处：《中国药房》2015年第23期3251-3252,共2页China Pharmacy

摘　　要：目的:观察替诺福韦酯(TDF)治疗多重耐药慢性乙型肝炎(CHB)的短期疗效及不良反应。方法:回顾性分析32例多重耐药CHB患者病历资料,所有患者治疗前均进行乙型肝炎病毒(HBV)耐药基因检测,存在多位点耐药,并给予TDF口服治疗。观察TDF治疗前、后丙氨酸氨基转移酶(ALT)复常率、HBV-DNA阴转率、乳酸、肾功能等指标。结果:治疗第3个月时,ALT复常率达100%,治疗半年时HBV-DNA阴转率达96.88%,治疗中患者未出现乳酸水平升高及肾功能异常。结论:TDF治疗多重耐药CHB疗效迅速,未出现明显不良反应。OBJECTIVE：To observe the short-term efficacy and ADR of tenofovir disoproxil fumarate（TDF）in the treatment of multi-drug resistant chronic hepatitis B（CHB）. METHODS：32 patients with multi-drug resistant CHB were analyzed retrospectively,and HBV drug-resistant genes were detected before treatment;there were a number of points to resistance;they were gave TDF orally. The recovery rate of serum alanine aminotransferase（ALT）,HBV-DNA conversion rate,lactic acid and renal function were observed before and after treatment. RESULTS：The recovery rate of ALT reached 100% at 3 months,and the conversion rate of HBV-DNA reached 96.88%. The lactic acid levels and renal dysfunction was not found during treatment. CONCLUSIONS：TDF take effect quickly on multi-drug resistant CHB,and no obvious ADR is found.

关 键 词：替诺福韦酯 多重耐药 慢性乙型肝炎 

分 类 号：R453.9[医药卫生—治疗学]