丹参酮Ⅱ_A磺酸钠联合前列地尔治疗急性脑梗死的疗效观察  

Efficacy Observation of Tanshinone Ⅱ_A Sulfonate Combined with Alprostadil in the Treatment of Acute Cerebral Infarction

作　　者：包晗[1] 卢弢[1] 陶晨[2] 

机构地区：[1]东南大学附属第二医院药学部,南京210003 [2]东南大学附属第二医院肝内科,南京210003

出　　处：《中国药房》2015年第23期3287-3289,共3页China Pharmacy

摘　　要：目的:观察丹参酮ⅡA磺酸钠联合前列地尔治疗急性脑梗死的临床疗效及安全性。方法:选取急性脑梗死患者56例,按随机数字表法分为治疗组(36例)和对照组(20例)。对照组患者给予丹参酮ⅡA磺酸钠60 mg静脉滴注,qd;治疗组患者在对照组的基础上半小时内加用前列地尔注射液10μg静脉滴注,30min内滴注完毕,qd,两组疗程均为10d。疗程结束后评价患者临床疗效及日常生活能力评分(BI)。结果:治疗组有效率为91.67%,对照组有效率为75.00%,治疗组疗效明显优于对照组,两组差异有统计学意义(P<0.05);两组患者治疗后BI评分优于治疗前,治疗后BI评分治疗组优于对照组,差异均有统计学意义(P<0.05);所有患者未见明显不良反应。结论:丹参酮ⅡA磺酸钠注射液联合前列地尔治疗急性脑梗死临床效果显著,安全性较好。OBJECTIVE：To observe clinical efficacy and safety of tanshinone ⅡA sulfonate combined with alprostadil in the treatment of acute cerebral infarction. METHODS：56 patients with acute cerebral infarction were randomly divided into treatment group（36 cases）and control group（20 cases）. Control group was given tanshinone ⅡA sulfonate 60 mg intravenously,qd,for 10 days. Treatment was additionally given Alprostadil injection 10 μg intravenously,30 min drop lrote,qd,the two group for 10 days,on the basis of control group. Therapeutic efficacy and BI were observed at the end of a treatment course. RESULTS：The effective rate of treatment group and control group were 91.67% and 75.00%,with statistical significance（P〈0.05）. BI score of 2groups after treatment were better than before,and the treatment group was better than the control group after treatment,with statistical significance（P〈0.05）. No obvious ADR wad found in both groups. CONCLUSIONS：Tanshinone ⅡA sulfonate combined with alprostadil is effective in the treatment of acute cerebral infarction with good safety.

关 键 词：丹参酮ⅡA磺酸钠 前列地尔 脑梗死 

分 类 号：R969.3[医药卫生—药理学]