抗N-甲基-D-天冬氨酸受体脑炎合并多处感染患者的药学监护  

Pharmaceutical Care for a Patient with Anti-N-methyl-D Aspartate Receptor Encephalitis Complicating with Multiple Organ Infections

作　　者：张丽新[1,2] 史国兵[1] 付曼曼[1] 樊蓉[1] 宋娟[1,2] 姜珊[1,2] 党大胜[1] 

机构地区：[1]沈阳军区总医院药剂科,沈阳110840 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国药房》2015年第23期3294-3297,共4页China Pharmacy

摘　　要：目的:探讨临床药师对抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎合并多处感染患者开展药学监护的方法。方法:以1例临床病例为切入点,分析临床药师在抗NMDAR脑炎合并多处感染治疗方案中的药学监护点,从抗菌药物的选择、药动学角度建议给药方法,对药品不良反应处理、营养支持等方面提出建议。结果:通过实施药学监护,临床药师及时解决了患者肝功能异常等不良反应,患者症状逐渐好转直至出院。结论:临床药师通过对患者的药学监护,排查用药安全隐患,避免严重不良反应的发生。OBJECTIVE：To explore the methods of clinical pharmacists providing pharmaceutical care for a patient with N-methyl-D-aspartate receptor（NMDAR）encephalitis complicating with multiple organ infections. METHODS：Taking one clinical case as breakthrough point,the points of pharmaceutical care provided by clinical pharmacists for NMDAR encephalitis complicating with multiple organ infections were analyzed,so as to put forward the suggestions in the field of antibiotics selection,medication approach based on pharmacokinetics,ADR disposal and nutrition support. RESULTS：Clinical pharmacists applied pharmaceutical care to resolve ADR as abnormal liver enzyme timely,and the symptom had been improved gradually. Then the patient was discharged from the hospital. CONCLUSIONS：Clinical pharmacists provide pharmaceutical care and screen the possible risk of drug use to avoid the occurrence of severe ADR.

关 键 词：抗N-甲基-D-天冬氨酸受体脑炎 感染 药学监护 临床药师 

分 类 号：R982[医药卫生—药品] R283.624[医药卫生—药学]