CXC趋化因子受体-4和生存素在非小细胞肺癌组织中的表达及其临床意义  

CXC chemokine receptor-4 expression is correlated with Survivin expression and poor survival in non- small lung cancer

作　　者：谢颂平[1] 毛志福[1] 康敢军[1] 江文洋[1] 黄杰[1] 梁健[1] 付印[1] 

机构地区：[1]武汉大学人民医院胸外科,430060

出　　处：《中华实验外科杂志》2015年第8期1792-1794,共3页Chinese Journal of Experimental Surgery

基　　金：湖北省自然科学基金重点资助项同（2014CFA070）

摘　　要：目的探讨CXC趋化凶子受体4（CXCR4）和生存素（Survivin）蛋白在非小细胞肺癌中的表达及其临床意义。方法应用免疫组织化学法检测64例肺癌组织标本及癌旁组织CXCR4和Survivin的表达，分析其表达与临床病理参数及预后的关系。结果64例肺癌组织中有41例CXCR4蛋白阳性表达干丌43例Survivin蛋白阳性表达，阳性表达率分别为64．1％和67．2％，正常肺组织呈阴性表达（P〈0．01）；CXCR4和Survivin蛋白表达与TNM分期、淋巴结转移和组织分化程度有关（P〈0．05）；肺癌中CXCR4和Survivin蛋白表达呈正相关（r=0．448P〈0．05）。结论CXCR4和Survivin蛋白在肺癌中高表达，两者在肺癌的发展中相互促进。Objective To investigate the expression of CXC chemokine receptor -4 （CXCR4） and Survivin in non - small lung cancer and the mechanism. Methods Immunohistochemical streptavidin - pero- sidase technique was used to detect the expression of CXCR4 and Survivin in 64 cases of non - small lung cancer tissues. Subsequently, the associations between CXCR4 expression, Survivin expression, CXCR4/ Sarvivin coexpression and clinicopathologic factors were assessed, and survival analyses were peribrmed. Results In total, 41 （64. 1%） patients expressed CXCR4, 43 （67.2%） expressed Survivin, and 34 （ 82.9% ） coexpressed CXCR4 and Survivin. Significant association between CXCR4 and Survivin expres- sion was observed （ r = 0. 448 ） in non - small lung cancer tissues. The expression of CXCR4 was correlated wilh tmnor differentiation, TNM stage and lymph node metastasis （P 〈 0. 05 ）, but not with histological types, gender and age （P 〉 0. 05 ）. The positive rate of Survivin was correlated with differentiation, clinical staging and lymph node metastasis （P 〈 0. 05 ） , but not with gender, age and histological types （P 〉 0. 05 ）. Conclusion The high expression of CXCR - 4 and Survivin may contribute to metastasis, invasion and lymph node metastasis of non - small lung cancer.

关 键 词：非小细胞肺癌 CXC趋化因子受体-4 生存素 

分 类 号：R512.91[医药卫生—内科学]