粘质沙雷氏菌在免疫调节及抗肿瘤方面的应用  

Application of Serratia Marcescens in Immunomodulatory and Anti-tumor

作　　者：张帅[1] 卢磊[1] 王靖瑶[1] 王天女[1] 

机构地区：[1]东北林业大学,黑龙江哈尔滨150040

出　　处：《黑龙江医药》2015年第4期718-721,共4页Heilongjiang Medicine journal

摘　　要：时至今日,肿瘤依然人类健康的重大威胁,而治疗肿瘤的化学治疗方法会在杀死肿瘤细胞的同时对正常细胞造成不可逆的损害,由此在肿瘤治疗的研究重心逐步转向多糖类等低毒害药物上。从粘质沙雷氏菌细胞壁提取出的灵杆菌脂多糖有较好的免疫调节和抗肿瘤作用,且灵杆菌脂多糖毒性比其他细菌内毒素毒性要低,更适合用于相关治疗。本文将重点介绍粘质沙雷氏菌相关理化性质及其次生代谢产物,粘质沙雷氏菌脂多糖的提取以及在医学方面的作用。Today, the tumor is still major threats to human health, and the chemical treatment of the tumor treatment would kill the tumor cells and cause irreversible damage to normal cells, resulting in tumor therapy research focus gradually in low toxic drugs, such as polysaccharide. Lipopolysaccharides of bacterium prodigiosum was extracted from Serratia marcescens, it has good function in immunity and anti-tumor, and its toxicity is lower than other bacterial endotoxin toxicity, more suitable for relevant treatment.This arti- cle focuses on serratia marcescens related physical and chemical properties and its secondary metabolites, Serratia marcescens fat polysaccharide extraction as well as in the role of the medicine.

关 键 词：粘质沙雷氏菌 灵菌红素 灵杆菌脂蛋白 抗肿瘤 

分 类 号：R378[医药卫生—病原生物学]