基于BCS系统Ⅳ类药物提高口服生物利用度的研究进展  

Progress in Improving Oral Bioavailability Based on BCS System IV Drugs

作　　者：张凤娇[1] 刘明玉[1] 单柏松 李霞[1] 王祺茹 杨志欣[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《黑龙江医药》2015年第4期721-724,共4页Heilongjiang Medicine journal

基　　金：黑龙江中医药大学"优秀创新人才支持计划"项目(2012);黑龙江省自然科学基金(No.D200744);黑龙江省自然科学基金(No.D200627);黑龙江省教育厅骨干教师资助项目(No.1251G058)

摘　　要：目的:综述BCS-Ⅳ类药物提高口服生物利用度的方法。方法:阅读有关该类药物中外文献综合阐述。结果:BCS-Ⅳ类药物可以通过提高溶出速率、增加生物膜通透性,并从同时增加溶出速率和生物膜通透性等途径提高生物利用度。结论:BCS-Ⅳ类药物的溶出速率慢,生物利用度低的问题已经通过新技术、新剂型得到良好的解决,为BCS-Ⅳ类药物的研究及应用提供基础。Objective： To review the method of improve the oral bioavailability of BCS- IV drugs. Methods： By reviewing the related literature at domestic and abroad to comprehensively expound. Results： BCS-IV drugs can improve the bioavailability by ways such as increase dissolution rate and biological membrane permeability, at the same time increase both of the dissolution rate and membrane permeability. Conclusion： The problem of BCS- IV drug has been solved successfully by the new dosage forms and new technology that provide the basis for the further study and application to BCS- IV drugs.

关 键 词：BCS-Ⅳ类药物 溶出速率 膜通透性 生物利用度 

分 类 号：TQ464[化学工程—制药化工]