盐酸帕罗西汀片治疗抑郁症疗效分析  

The adverse reaction and clinical curative effect of paroxetine in treatment of depression

作　　者：孙娟 李向阳[2] 

机构地区：[1]西宁市医疗机构药事服务监督管理中心市一调配站中心药房,青海西宁810000 [2]青海大学医学院药物分析教研室,青海西宁810001

出　　处：《西部医学》2015年第8期1169-1171,共3页Medical Journal of West China

基　　金：国家自然科学基金(30960457)

摘　　要：目的评价盐酸帕罗西汀治疗抑郁症的效果和不良反应。方法将2012年1月～2013年1月收治的98例抑郁症患者随机分为帕罗西汀组和文拉法辛组各49例,两组患者分别给予盐酸帕罗西汀和文拉法辛治疗,连续治疗6周。分别在第1、2、4、6周末对两组患者进行HAMD和HAMA、病情严重程度CGI-SI及不良反应量表TESS评定,并对数据进行统计学分析处理。结果帕罗西汀组在第1周HAMD和HAMA评分显著低于文拉法辛组,差异有统计学意义（P〈0.05）;其他时间评分无明显差异（P〉0.05）;帕罗西汀组CGI-SI评分在第1、2周时显著低于文拉法辛组,差异有统计学意义（P〈0.05）,帕罗西汀组不良反应TESS评分在整个观察周期都低于文拉法辛组（均P〈0.05）。结论帕罗西汀治疗抑郁症起效快,不良反应较轻患者能够耐受,可以作为抑郁症治疗的一线用药。Objective To evaluate the therapeutic effect and adverse reactions of paroxetine hydrochloride on trea- ting depression. Methods 98 patients with depression were randomly divided into paroxetine group （49 cases） and rafa symplectic group （49 cases）. The patients were given paroxetine hydrochloride and rafa treatment. HAMD, HAMA and illness severity CGI - SI and adverse reaction scale TESS at 1, 2, 4 and 6 weekend were observed. The experimental data were analyzed. Results HAMA and HAMD Scores of paroxetine group in 1st week were significantly lower than that of venlafaxine group. The difference is statistically significant （P〈0.05）. CGI - SI score of paroxetine group was signifi- cantly lower than that of venlafaxine group in 1, 2 weeks. The difference is statistically significant. The adverse reactions TESS score in the whole observation period of paroxetine group lower was than that of venlafaxine group. There are significant differences （P〈0.05）. Conclusion Paroxetine treating depression can get quick effect, which can be used as a first treatment of depression medication.

关 键 词：帕罗西汀 抑郁症 不良反应 

分 类 号：R969.4[医药卫生—药理学]