氟比洛芬酯和帕瑞昔布钠对腰椎间盘术后疼痛影响  

Efficacy of intravenous flurbiprofen and parecocib-sodium on postoperative pain after lumbar intervertebral disk surgery

作　　者：邓嘉陵 李军祥[2] 杨小霖[2] 

机构地区：[1]南充市东方医院麻醉科,四川南充637000 [2]川北医学院附属医院麻醉科,四川南充637000

出　　处：《西部医学》2015年第8期1187-1189,共3页Medical Journal of West China

基　　金：南充市科技局支撑项目(2011A1103)

摘　　要：目的观察静脉使用氟比洛芬酯和帕瑞昔布钠对腰椎间盘术后患者疼痛的影响。方法 60例患者随机分为3组,分别接受50mg氟比洛芬酯(F组)、40mg帕瑞昔布钠(P组)和生理盐水对照(C组)。药物溶于0.9%生理盐水100ml,15min左右缓慢输注,对照组给予100ml生理盐水。所有患者接受常规全身麻醉,在手术切口关闭完成时,第一次给予镇痛药物,12h后第二次给予镇痛药。分别于术后0、2、6、12、24小时对患者进行VAS评分。记录患者术后恶心、呕吐、尿潴留、瘙痒等不良事件的发生情况。结果术后2小时F组和P患者VAS评分均较C组为低(P<0.05),且P组低于F组(P<0.05)。术后6小时P组VAS低于F组和C组(P<0.05)。术后3组患者阿片类药物用量无统计学差异(P>0.05)患者术后不良反应发生率3组没有统计学差异(P>0.05)。结论注射用氟比洛芬酯和帕瑞昔布钠作为腰椎间盘手术后患者PCIA的辅助镇痛药物,能有效降低阿片类药物的使用量,降低了不良反应的发生率。Objective To observe the efficacy of intravenous flurbiprofen and parecocib-sodium on postoperative pain after lumbar intervertebral disk surgery. Methods 60 patients with ASA Ⅰ～Ⅱ scheduled for elective lumbar intervertebral disk surgery under general anesthesia were included in the study. Patients were treated using patient-controlled analgesia for 24 hours after surgery and randomized to receive IV flurbiprofen 50mg, parecoxib-sodium 40 mg, or isotonic saline （placebo）, respectively. The the visual analogue scale （VAS） and related side effects were observed. Results The VAS either in the group P （parecoxib-sodium） or group F （flurbiprofen） was lower than that in the control 6 hours after surgery（P〈0. 05）, and the VAS in the group P was the lowest among the three groups （P〈0.05）. There were no significant differences about side-effects among the three groups （P〈 0. 05）. Conclusion The pain intensity during 6 hours after the lumbar intervertebral disk surgery was significantly decreased by intravenous flurbiprofen or parecocib-so- dium, and without the increase of side-effects. Both flurbiprofen and parecocib-sodium can be used for supplemental analgesics to morphine patient-controlled analgesia, which decreased the requirement for opioids and the incidence of sideeffects.

关 键 词：氟比洛芬酯 帕瑞昔布钠 疼痛 

分 类 号：R681.55[医药卫生—骨科学]