SIRT1氧化应激通路与疾病的关系  

The relationship between SIRT1oxidative stress pathways and disease

作　　者：杨熙 董文斌 

机构地区：[1]四川医科大学附属医院新生儿科,四川泸州646000

出　　处：《西部医学》2015年第8期1275-1278,共4页Medical Journal of West China

基　　金：中华儿科杂志第二届双鹤珂立苏科研基金;四川省教育厅科研基金(08ZA150);四川省卫生厅科研课题(90191)

摘　　要：SIRT1是一类依赖烟碱腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)的第三类组蛋白去乙酰化酶,这种蛋白从古细菌到人类都具有高度保守性。SIRT1在人体组织中广泛表达,运动、能量限制可以上调SIRT1表达。SIRT1通过组蛋白/非组蛋白去乙酰化基作用影响基因的转录,在抵抗各种应激,调节细胞凋亡、细胞能量代谢以及细胞老化等方面发挥重要作用。目前,一些研究已经证实SIRT1在与衰老相关性疾病中及氧化刺激中具有保护作用,如神经退行性疾病、心血管系统疾病、肾脏系统疾病、内分泌系统疾病等。SIRT1 is a highly conservative NAD＋-dependent class m histone deacetylase,whichis widely expressed in human tissues and motion, energy restriction can upregulate it＇s expression. SIRT1 can affect gene transcription via histone and non histone deacetylation,and play an important I role in against various stress, regulation of cell apoptosis, cell metabolism and cell senescence. At present, some studies have confirmed that SIRT1 has protective effects on aging related diseases and oxidation stimulation such as neurodegenerative disease, cardiovascular system disease, kidney system disease, endocrine system disease.

关 键 词：SIRT1 氧化应激 疾病 SIRT1 

分 类 号：R446.69[医药卫生—诊断学]