右美托咪定对不同年龄患者顺行性遗忘作用的影响  

Effects of dexmedetomidine on the anterograde amnesia in patients with different ages

作　　者：胡志超[1] 孔莉[1] 许鹏程[2] 李颖[1] 董晓辉[1] 

机构地区：[1]商丘市第一人民医院麻醉科,河南476100 [2]徐州医学院江苏省麻醉学重点实验室,徐州221002

出　　处：《中国临床新医学》2015年第8期726-728,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的：观察右美托咪定对不同年龄患者顺行性遗忘作用的影响。方法选择美国麻醉医师学会（ ASA）Ⅰ～Ⅱ级、年龄18～84岁，在腰硬联合麻醉下复合右美托咪定行下腹部（剖宫产术除外）手术患者120例，其中男73例，女47例。根据患者年龄的不同分为四组：A组（23±4）岁， B组（36±3）岁， C组（65±3）岁，D组（75±5）岁。所有患者均给予右美托咪定负荷量1μg／kg，泵入10 min之后以0．2μg· kg^－1· h^－1剂量维持。术后24 h回访患者并评定右美托咪定的顺行性遗忘作用。结果 A组和B组右美托咪定顺行性遗忘作用无明显不同（P＞0．05），而C组与D组较前两组右美托咪定顺行性遗忘作用比较明显（P＜0．05），并随年龄的增大明显增加（ P＜0．05）。结论右美托咪定具有一定的顺行性遗忘作用，且对老年患者更为明显。Objective To study the effects of dexmedetomidine on the anterograde amnesia in patients with different ages.Methods One hundred and twenty ASAⅠ~Ⅱpatients, age from 18 years to 84 years, 73 cases of male and 47 cases of female , who were dministered spinal-epidural anesthesia combined with dexmedetomidine and performed operation on hypogastrium （ except for caesarean section ） .All patients were randomly divided into four groups：group A, group B, group C and group D.Dexmedetomidine（1μg/kg） was infused intravenously for 10 min and the maintenance dose was 0.2 μg· kg^-1· h^-1.The anterograde amnesia degree of dexmedetomidine was as-sessed 24 h after the operation .Results There was no significant difference in the anterograde amnesia of dexmedeto -midine between group A and group B （ P〉0.05 ） , while there were significant differences in group C and group D compared with both group A and group B （ P〈0.05 ） .Conclusion Anterograde amnesia occurs after using dexme-detomidine in elderly patients and with aging , the anterograde amnesia becomes more severe .

关 键 词：右美托咪定 顺行性遗忘 腰硬联合麻醉 年龄 

分 类 号：R971.2[医药卫生—药品]