不同剂量乙肝免疫球蛋白联合乙肝疫苗阻断乙肝病毒母婴传播的疗效比较  

Comparison of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns

作　　者：谢若欣[1] 杨洁芳[1] 霍乐颍[2] 

机构地区：[1]珠海市妇幼保健院儿保科,广东519000 [2]珠海市妇幼保健院新生儿科,广东519000

出　　处：《中国临床新医学》2015年第8期754-757,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的比较不同剂量乙肝免疫球蛋白(HBIG)联合乙肝疫苗阻断乙肝病毒母婴传播的疗效。方法将HBs Ag阳性孕妇分娩的新生儿124例分为双阳组60例和单阳组64例。双阳组按家长的意愿分为双阳大剂量组30例和双阳小剂量组30例,单阳组亦分为单阳大剂量组和单阳小剂量组各32例。新生儿出生后6 h内,大剂量组予肌注HBIG 200 U,小剂量组予肌注HBIG 100 U;同时联合应用乙肝疫苗。一周岁时检测HBV血清学标志物(乙肝五项)。结果在双阳组中大剂量和小剂量HBIG的乙肝母婴阻断率分别为93.3%和83.3%;在单阳组中大剂量和小剂量HBIG的乙肝母婴阻断率分别为100.0%和96.9%,差异无统计学意义(P>0.05)。结论孕妇HBs Ag阳性时,新生儿出生后要及时注射HBIG,用量100 U或200 U均可。Objective To explore the efficacy of different doses of hepatitis B immune globulin in blocking infection of hepatitis B virus by mother-to-fetus transmission for newborns .Methods 124 newborns who were born by HBsAg-positive mothers in our hospital were divided into single positive group （n=60） and double positive group（n=64 ） .The patients in the double positive group were randomly divided into a small dose double positive subgroup （ n=30） and a big dose double positive subgroup （n=30）, and the patients in the single positive group were randomly di-vided into a small dose double positive subgroup （n=32） and a big dose double positive subgroup （n=32）.The big dose groups were intramuscularly injected with HBIG 200 U and the small dose groups were intramuscularly injected with HBIG 100 U, with all groups in combination of hepatitis B vaccine within 6 hours after childbirth .HBV serologi-cal markers（HB 5 tests）were detected at the age of one.Results There were no significant differences in blocking rate of vertical transmission of hepatitis B between the large dose （200 U） and the small dose（100 U） of HBIG in both double positive group and single positive group .Conclusion Newborns of HBsAg-positive mothers should be in-jected with HBIG in time either in dose of 100 U or 200 U.

关 键 词：乙肝免疫球蛋白 乙型肝炎病毒 母婴传播 

分 类 号：R512.62[医药卫生—内科学]