复方半边莲凝胶制备工艺优化  

Optimization of compound lobelia gel in preparation process

作　　者：陈琼[1] 王海燕[1] 余红霞[1] 李青青[1] 杨俊杰[1] 

机构地区：[1]信阳农林学院信阳市中药资源开发工程技术研究中心信阳市中药质量分析检测重点实验室,河南信阳464000

出　　处：《中国生化药物杂志》2015年第3期162-165,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：河南省科技攻关项目(132102310266)

摘　　要：目的考察影响复方半边莲凝胶制备工艺的各因素,确定复方半边莲凝胶最佳制备工艺条件。方法在单因素实验基础上,以成型性、涂展性、稳定性的综合作用为指标,采用正交试验设计对卡波姆-940用量、载药量、5%羟苯乙酯乙醇溶液和三乙醇胺用量进行考察,并用高效液相色谱法测定所制凝胶中野黄芩苷的含量。结果确定复方半边莲凝胶最佳处方工艺为:以0.25 g卡波姆-940为凝胶基质,2 g 10%月桂氮卓酮无水乙醇溶液为促渗剂,1.0 g三乙醇胺为p H调整剂、0.4 g甘油为保湿剂、0.3 g 5%羟苯乙酯乙醇溶液为防腐剂;载药量为每1 g凝胶含1 g饮片。结论复方半边莲凝胶制备工艺简便,质地均匀细腻,稳定性良好。Objective To study the factors which affect the preparation of compound lobelia gel and establish the optimal preparation process. Methods Based on single factor test, formability, spread performance, stability were used as comprehensive evaluation indicators to select the preparation process by orthogonal design, taking the dosage of carbopol-940, drug loading, 5% hydroxy ethyl benzene ethanol solution and triethanolamine as factors.The content of scutellarin in gel was determined by HPLC.Results The best prescription of compound lobelia gel was as follows： substrat of carbopol-940 was 0.25 g, 10% Azone for promoting the permeability was 2 g, pH regulator of triethanolamine was 1.0 g, moisturizer of glycerol was 0.4 g; preservatives of 5% ethylparaben ethanol solution was 0.3 g; the drug loading was 1 g processed herbs per 1 g gel. Conclusion The preparation process of compound lobelia gel is simple, the product is texture and delicate stable.

关 键 词：复方半边莲 凝胶 工艺 正交试验 

分 类 号：R283.6[医药卫生—中药学]