Apelin/APJ:血管功能调节因子和药物治疗新靶点  

Apelin/APJ: Vascular Function Regulatory Factor and New Targets for Drug Treatment

作　　者：曹建刚[1] 李兰芳[1] 陈临溪[1] 

机构地区：[1]南华大学药物药理研究所,衡阳421001

出　　处：《生物化学与生物物理进展》2015年第8期721-732,共12页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81270420;81470434);湖南省自然科学基金省市联合(衡阳)基金重点项目(12JJ8013);湖南省自然科学基金(14JJ3102);湖南省十二五重点学科建设项目;分子靶标新药研究协同创新中心(湘教通(2014)405号)资助~~

摘　　要：Apelin(APJendogenousligand)是血管紧张素Ⅱ1型受体相关蛋白(angiotensin receptor-like 1,APJ)的内源性配体.Apelin/APJ系统在机体内广泛分布,在众多血管系统表达水平较高,如心血管系统、肺血管系统等.研究发现,apelin可调节血管张力,促进血管平滑肌细胞增殖、视网膜血管新生以及单核细胞向内皮细胞黏附,促进肝门静脉和冠状动脉侧枝形成等.本文就apelin调节血管功能及其相关疾病(高血压、肺动脉高压、动脉粥样硬化、胶质瘤、肺癌、门静脉高压、糖尿病血管并发症等)进行综述,揭示了apelin与血管及其相关疾病的内在联系,表明apelin/APJ可作为血管疾病的治疗靶点.Apelin is the endogenous ligand of apelin-angiotensin receptor-like 1 （APJ）. Apelin/APJ system widely distributed in the body, with high expression level in the vascular system, such as cardiovascular system, pulmonary vascular system. The study found that apelin can regulate vascular tone and inducevascular smooth muscle cell proliferation, promote retinal neovascularization, mononuclear cell adhesion to endothelial cells and hepatic portal vein and coronary collateral formation. In this review, we summarized the actions of apelin regulating blood vessel function and the related diseases （hypertension, pulmonary hypertension, atherosclerosis, glioma, lung cancer, portal hypertension and diabetic angiopathy）. Moreover, we revealed the inner connection of apelin with vascular and its related diseases, and show that apelirdAPJ can be used as therapeutic targets of vascular disease.

关 键 词：APELIN APJ 血管平滑肌细胞 自噬 血管新生 血管重构 高血压 动脉粥样硬化 

分 类 号：Q7[生物学—分子生物学] R3[医药卫生—基础医学]