PVC输液器与20种药物的相容性  

Compatibility of PVC Infusion Sets with Twenty Injectable Drugs

作　　者：徐翠玲[1] 贾铭婧 崔钰琪 魏岚[1] 孙立新[1,2] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2015年第8期879-885,共7页Chinese Journal of Pharmaceuticals

基　　金：辽宁省科学事业研究公益基金资助项目(2012002010);辽宁省教育厅创新团队项目(LT2012018)

摘　　要：考察了聚氯乙烯(PVC)输液器与20种注射液的相容性。以不含增塑剂的聚烯烃热塑性弹性体(TPE)输液器为对照组,将20种注射液按说明书配成临床输液浓度,分别经PVC和TPE输液器流出。采用HPLC或UV法测定流出液中的药物浓度,并与0 h时比较,同时比较流经输液器前后的药物浓度变化。采用HPLC法测定流出液中的邻苯二甲酸二-(2-乙基己基)酯(DEHP)。结果显示,尼莫地平和卡莫司汀注射液流经PVC输液器时存在严重的吸附作用;单硝酸异山梨酯、氢化可的松、盐酸胺碘酮、盐酸氯丙嗪和氟尿嘧啶注射液流经PVC输液器时也存在较弱的吸附作用;硝酸甘油和硝酸异山梨酯注射液流经PVC输液器后出现新生成物质峰;盐酸胺碘酮注射液流经PVC输液器后有DEHP溶出。The compatibilities of PVC infusion sets with twenty kinds of injections were investigated, with polyolefin thermoplastic elastomer （TPE） infusion sets as the control group. Twenty kinds of injections were prepared separately as per actual concentration needed by the clinic according to the instructions, and then flowed through PVC and TPE infusion sets. The drug concentrations both before and after passing through the transfusion system were determined by HPLC or UV, and it was compared with that at 0 h. An HPLC method was used to determine the contents of DEHP leaching from PVC infusion sets. The results showed that there was serious absorbability for PVC infusion sets to nimodipine and carmustine, and obvious absorbability to isosorbide mononitrate, hydrocortisone, amiodarone hydrochloride, chlorpromazine hydrochloride and fluorouracil when passing through PVC infusion sets. Peaks of unknown compounds were observed in the chromatography of nitraglycerin and isosorbide esters. DEHP was detected in the injection of amiodarone hydrochloride after flowing through PVC infusion sets.

关 键 词：聚氯乙烯 热塑性弹性体 输液器 药物吸附 DEHP溶出 

分 类 号：R943[医药卫生—药剂学]