Fission yeast telomere-binding protein Tazl is a functiona out not a structural counterpart of human TRF1 and TRF2  

作　　者：Wei Deng Jian Wu Feng Wang Junko Kanoh Pierre-Marie Dehe Haruna Inoue Juan Chen Ming Lei 

机构地区：[1]National Center for Protein Science ShanghaL State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2]Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, M1 48109, USA [3]Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, M1 48109, USA [4]Institutes for Biological Sciences, Osaka University, Suita, Osaka, Japan [5]Telomere Biology Laboratory, Cancer Research UK, London WC2A 3PX, UK

出　　处：《Cell Research》2015年第7期881-884,共4页细胞研究（英文版）

摘　　要：Dear Editor, Telomeres, the natural ends of linear eukaryotic chro- mosomes, are essential for cell viability and genome integrity [ 1 ]. In mammalian cells, telomere repeat factors 1 and 2 （TRF1 and TRF2） are the first two identified mammalian telomere-binding proteins that play essential roles in telomere homeostasis and maintenance [2, 3]. Both TRF1 and TRF2 contain a central TRF homology （TRFH） domain and a C-terminal DNA-binding Myb domain （Supplementary information, Figure S1A） [4].

关 键 词：端粒结合蛋白 裂殖酵母 结构相 DNA结合结构域 哺乳动物细胞 人类 细胞活力 C-末端 

分 类 号：Q26[生物学—细胞生物学] S562[农业科学—作物学]