血清抗精子抗体与精液检验在男性不育症中的相关分析  

Semen and serum anti-sperm antibodies in male infertility test correlation analysis

作　　者：吴殿水[1] 王嘉[1] 田玫玲[1] 

机构地区：[1]山东大学附属省立医院检验科,山东济南250022

出　　处：《国际检验医学杂志》2015年第15期2147-2149,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨精液与血清中抗精子抗体的检验在男性不育症中的意义及分析。方法选取于2012年6月至2014年5月前来该院检测的95例不育男性患者作为该次研究实验对象,另选取来该院经排查无不育症的健康男性30例作为对照组,测定其血液与精液中抗精子抗体(AsAb)水平和精液常规检查并进行分析比较。结果观察组患者精液中精子存活率、精液液化时间和a+b级精子活力百分比均低于对照组健康男性,差异有统计学意义(P<0.05)。AsAb阳性患者精子存活率、精液液化时间和a+b级精子活力百分比均低于AsAb检测呈阴性的不育患者,差异有统计学意义(P<0.05)。观察组患者血清中白细胞介素-12(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的水平较对照组男性显著升高,两组比较差异有统计学意义(P<0.05)。AsAb阳性患者血清中IL-2和IL-6水平与AsAb阴性患者相近,但TNF-α水平比AsAb检测呈阴性的患者组明显上升,两组比较差异有统计学意义(P<0.05)。结论血液中抗精子抗体与精液各项参数有一定的关联,精液与血液中抗精子抗体的检测可以作为一种诊断不育症患者的手段,值得广泛推荐。Objective To discussion and analysis of the significance of semen and serum anti‐sperm antibodies in the test in male infertility.Methods 95casesofinfertilemalepatientsassubjectsinthisstudyfromJune2012toMay2014tocometoourhospi‐tal ,others choose to our hospital after medical investigation and no normal healthy male infertility 30 cases as controls group ,meas‐ured in blood and semen of anti‐sperm antibodies content and semen examination ,analysis and comparison .Results Semen of pa‐tients in the observation group sperm viability ,semen liquefaction time and a ＋ b grade sperm motility percentages were lower than in the control group healthy men ,the two groups was statistically significant （P〈0 .05） .Sperm viability ,semen liquefaction time and a ＋ b grade sperm motility percentage of patients AsAb positive group were lower than AsAb tested negative for infertile pa‐tients ,the two groups was statistically significant（P〈0 .05） .Patients in the observation group IL‐2 ,IL‐6 ,and the content of TNF‐αcompared with the healthy control group of men increased significantly between the two groups was statistically significant （P〈0 .05） .AsAb positive serum IL‐2 group ,and IL‐6 levels and AsAb negative groups are similar ,but TNF‐αcontent than AsAb tested negative patients was significantly increased ,the two groups was statistically significant （P〈0 .05） .Conclusion Anti‐sperm anti‐bodies in the blood and semen parameters have some relevance ,semen and blood detection of anti‐sperm antibodies can be used as a means of diagnosis of infertility patients ,it is worth widely recommended .

关 键 词：精液 抗精子抗体 男性不育症 

分 类 号：R698.2[医药卫生—泌尿科学] R446.19[医药卫生—外科学]