中医辨证多途径给药治疗中重度膝关节骨关节炎临床研究  

Clinical Study on the Treatment of Moderate and Severe Knee Osteoarthritis by Multiple Routes of Administration of Traditional Chinese Medicine Discriminate

作　　者：汪利合[1] 李慧英[1] 孟东方[1] 乔卫平[1] 赵鹏飞[1] 王韬[1] 

机构地区：[1]河南中医学院第一附属医院,河南郑州450000

出　　处：《中医学报》2015年第8期1196-1198,共3页Acta Chinese Medicine

基　　金：河南省重点中医学科(专科)学术带头人培养项目(豫中医2011 43号);河南省科技攻关项目(122102310186);河南省中医药科学研究专项(2013ZY03015)

摘　　要：目的:观察中医辨证多途径给药治疗中重度膝关节骨关节炎的临床疗效。方法:将符合中重度膝关节骨关节炎的96例患者随机分为治疗组和对照组,治疗组根据中医辨证给予独活寄生汤加减内服,外用消瘀定痛散,同时配合玻璃酸钠关节腔注射治疗;对照组口服扶他林片,外用吡啰昔康贴片,同时给予玻璃酸钠关节腔注射治疗。两组治疗后分别对疼痛和关节功能进行评分。结果:治疗后两组患者视觉模拟评分法(visual analogue scale,VAS)及关节功能评分(western ontario and mcmaster universities osteoarthritis index,WOMAC)均较治疗前降低,VAS评分治疗组治疗前为(68±23)分,治疗后为(22±16)分;对照组治疗前为(69±25)分,治疗后为(43±15)分。WOMAC功能评分治疗组治疗前为(66.8±12.1)分,治疗后为(20.6±12.8)分;对照组为(64.9±13.6)分,治疗后为(42.5±12.6)分。两组比较,差异有统计学意义(P<0.05),治疗组均优于对照组。结论:中医辨证多途径给药可以更好地缓解中重度膝关节骨关节炎引起的疼痛,改善关节功能功能。Objective：To observe the clinical study on the treatment of moderate and severe knee osteoarthritis by multiple routes of ad- ministration of TCM discriminate. Methods ：96 cases were randomly divided into treatment group and control group. The treatment group was given Duhuo Jisheng Tang by TCM discriminate, external use Xiaoyu Dingtong San, at the same time, coordinating anticular injec- tion with sodium hyaluronate. The control group was taken orally voltaren, external use piroxicampaster, at the same time, coordinating anticular injection with sodium hyaluronate. After the treatment, giving a mark for pain and joint function respectively. Results：After the treatment of the patients in the two groups, Visual Analogue Scale method （ Visual Analogue Scale/Score, VAS） and joint function Score （ Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC ） was reduced than before the treatment. The VAS Score was （68 ±23） points in the treatment group before the treatment,after the treatment was （22 ± 16） points. The VAS Score was （69 ±25） points in the treatment group before the treatment, after the treatment was （43 ± 15 ） points. WOMAC function score in treatment group was （66.8± 12.1 ） points before the treatment, after the treatment was （20.6 ± 12.8 ） points. WOMAC function score in treatment group was （64.9 ± 13.6） points before the treatment, after the treatment was （42.5 ± 12.6） points. Comparison the patients of the two groups, it was statistically siguificant（P 〈 0.05 ） ,the treatment group were superior to the control group. Conclusion： Multiple routes of administration of TCM discriminate in treating moderate and severe knee osteoarthritis can better ease moderately severe osteoarthritis pain, improve the function of joint function, is worthy of popularization and application.

关 键 词：中重度膝关节骨关节炎 多途径给药 独活寄生汤 消瘀定痛散 

分 类 号：R274.984.3[医药卫生—中西医结合]