糖尿病慢性肾脏疾病患者血清瘦素和血脂水平的变化及其临床意义的研究  

Study of the level of serum leptin and lipid in type 2 diabetes patients with chronic kidney disease

作　　者：王颖[1,2] 朱铁虹[1] 佟俊旺[3] 陈冬[2] 魏剑芬[2] 吴乃君[2] 盛佳曦[2] 戚晓渊[4] 毕西娟[5] 

机构地区：[1]天津医科大学总医院内分泌科,300052 [2]河北联合大学附属医院内分泌科 [3]河北联合大学公共卫生学院 [4]河北联合大学附属医院检验科 [5]河北联合大学冀唐学院

出　　处：《中国糖尿病杂志》2015年第8期711-713,共3页Chinese Journal of Diabetes

摘　　要：目的：探讨糖尿病慢性肾脏疾病（CKD）患者血清瘦素（Lep）和血脂水平的变化及其临床意义。方法根据UAER水平将120例T2DM患者分为＜30 mg／24 h组41例、30-299 mg／24 h组44例和≥300 mg／24 h组35例，另选取健康志愿者40名作为对照（NC）组。检测FPG、HbA1c、Lep及血脂各项。结果 CKD各组FPG、HbA1c、Lep、TG、TC、LDL‐C水平均高于NC组，HDL‐C低于NC组（P＜0.05）。30-299 mg／24 h组和≥300 mg／24 h组FPG、HbA1c、Lep、TC、TG、LDL‐C水平高于＜30 mg／24 h组，HDL‐C低于＜30 mg／24 h组，且≥300 mg／24 h组高于30-299 mg／24 h组（P＜0.05）。Lep水平与UAER呈正相关（P＜0.01）。结论 CKD患者HbA1 c、Lep、血脂水平均升高，且与微血管病变程度有关，提示 HbA1 c、Lep、血脂水平可预测CKD的进展。Objective To explore the changes of serum leptin and lipid levels in type 2 diabetes patients with chronic kidney disease （CKD） and its clinical significance. Methods 120 cases with T2DM were divided into 〈30 mg/24 h group（n=41） ,30-299 mg/24 h group（n=44） and ≥300 mg/24 h group （n=35） according to the UAER.40 healthy volunteers were selected as normal control （NC） group. FPG , HbA1 c ,serum leptin and lipid were measured. Results In the early stage of diabetic nephropathy group and middle—late stage group ,The levels of FPG ,HbA1 c ,Leptin ,TG ,TC and LDL‐C were higher ,and HDL‐C was lower in different CKD groups than in NC group （P〈 0.05）.The levels of FPG ,HbA1c , leptin ,TC ,TG LDL‐C were higher ,and HDL‐C was lower in 30-299 mg/24 h group and ≥300 mg/24 h group than in 〈30 mg/24 h group ,moreover those indexes were higher in ≥300 mg/24 h group than in 30-299 mg/24 h group （P〈 0.05）. Leptin level was positively correlated with UAER （P〈 0.01）. Conclusion HbA1 c ,leptin and lipid level is increased in CKD patients ,and correlated with the degrees of microvascular disease. The levels of HbA1 c ,leptin ,blood lipid levels can predict the progress of CKD.

关 键 词：糖尿病慢性肾脏疾病 糖化血红蛋白 瘦素 血脂 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]