粪菌移植治疗慢传输型便秘20例临床研究  

Fecal microbiota transplantation for treatment of slow transit constipation: A clinical study of 20 patients

作　　者：田宏亮[1] 丁超[1] 龚剑锋[1] 葛晓龙[1] 解廷斌 顾立立[1] 韦瑶[1] 李宁[1] 

机构地区：[1]南京大学医学院附属金陵医院普外科,江苏南京210002

出　　处：《中国实用外科杂志》2015年第8期873-875,共3页Chinese Journal of Practical Surgery

基　　金：江苏省临床医学科技专项课题(No.B12012006);江苏省普通高校研究生科研创新计划项目(No.KYLX15_0046)

摘　　要：目的探讨粪菌移植(FMT)治疗慢传输型便秘的有效性和安全性。方法选择2014年12月至2015年2月南京大学医学院附属金陵医院收治的20例明确有慢传输因素的慢性便秘病人,所有病人均行FMT治疗,记录移植治疗前后病人每周自主排便次数、Wexner便秘评分、胃肠生活质量及相关不良反应。治疗后随访8周。结果与治疗前比较,FMT治疗后第8周病人排便次数明显增加[(1.5±1.3)vs.(4.5±1.5)次/周],Wexner便秘评分明显下降[(15.7±3.5)vs.(7.5±1.6)分],GIQLI评分升高[(84.6±12.5)vs.(116.6±11.5)分],差异均有统计学意义(P<0.05)。随访期间疗效稳定,至第8周共12例病人获得临床改善,7例病人获得临床治愈。临床改善所需时间为(10.9±4.9)d。随访期间均未发生严重不良反应。结论 FMT治疗慢传输型便秘安全、有效,短期治疗效果良好。Objective To examine the safety and efficacy of fecal microbiota transplantation （FMT） for slow transit constipation （STC）. Methods Twenty patients with STC were enrolled in the prospective open-label study. All the patients were performed FMT. Autonomous defecation frequency, Wexner constipation scale, bowel movement and related adverse reaction per week around FMT were evaluated at each study visit. All the patients were followed up for 8 weeks. Results Compared with pre-FMT treatment, the patient＇ s stool frequency increased significantly [（1.5 ± 1.3） times/week vs. （4.5 ± 1.5） times/week] after eight weeks of treatment. Meanwhile, Wexner constipation scores demonstrated a significant reduction [ （15.7 ± 3.5） vs. （7.5 ± 1.6）] and GIQLI score increased remarkably [ （84.6 ± 12.5） vs. （116.6 ± 11.5）], which has significant difference statistically （P〈0.05）. There were 12 patients obtained clinical improvement and seven patients obtained clinical remission till to 8 weeks. FMT efficacy was stable and no serious adverse event occurred （luring the whole follow-up. Conclusion FMT is safe and effective for treating slow transit constipation and the short-term treatment effect is good.

关 键 词：粪菌移植 慢传输型便秘 排便次数 Wexner便秘评分 

分 类 号：R6[医药卫生—外科学]