益母草碱油包油微乳在小鼠体内组织分布研究  

Pharmacokinetics and Tissue Distribution of Leonurine Oil/Oil Microemulsion in Mice

作　　者：丁启 张祥[1] 孙亚楠[1] 刘子荣[1] 鲁传华[2] 

机构地区：[1]安徽中医药大学研究生部,安徽合肥230038 [2]安徽中医药大学药学院,安徽合肥230012

出　　处：《安徽中医药大学学报》2015年第4期92-96,共5页Journal of Anhui University of Chinese Medicine

摘　　要：目的探讨益母草碱油包油微乳剂和益母草碱混悬剂在动物体内药物代谢动力学特征和组织靶向性。方法采用高效液相色谱法测定小鼠血浆与组织中益母草碱浓度，计算药物代谢动力学参数。结果与混悬剂比较，益母草碱微乳剂在体内平均滞留时间提高了7h，其相对生物利用度为550．684％；益母草碱微乳剂AUC（0→∞），在小鼠各组织的分布整体提高到混悬组的3．626～26．265倍；益母草碱微乳剂在心、肺和脑组织的靶向指标分别为1．044、1．335和4．772。结论益母草碱油包油微乳提高了生物利用度，对脑组织具有较好的趋向性分布。Objective To investigate the pharmacokinetics and tissue distribution of leonurine oil/oil （O/O） mi- croemulsion and leonurine suspension in mice. Methods High-performance liquid chromatography was used to measure the concentration of leonurine in the plasma and tissues of mice and to calculate pharmaco- kinetic parameters. Results Compared with leonurine suspension, leonurine （O/O） microemulsion had the average residence time in vivo increased by about 7 hours, and its relative bioavailability was 550. 684%. The area under the time-concentration curve （0→∞） for leonurine （O/O） microemulsion in different tissues of mice increased to 3. 626-26. 265 times compared with that for leonurine suspension. The drug targeting index of leonurine （O/O） microemulsion in the heart, lung, and brain was 1. 044, 1. 335, and 4. 772, respectively. Conclusion The leonurine （O/O） emulsion has increased bioavailability and has a strong distribution in the brain.

关 键 词：益母草碱 微乳 药物代谢动力学 组织分布 靶向性 

分 类 号：R969.1[医药卫生—药理学]