抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染的疗效和安全性分析  

Clinical efficacy and safety analysis of antibiotic sequential therapy combined with transfer factor in treatment of children with acute lower respiratory tract infection

作　　者：成登菊[1] 

机构地区：[1]山西省晋中市第二人民医院儿科,030800

出　　处：《中国实用医刊》2015年第16期3-5,共3页Chinese Journal of Practical Medicine

摘　　要：目的：探讨抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染的临床疗效及安全性。方法将180例急性下呼吸道感染儿童随机分成两组，每组90例。对照组给予抗生素序贯疗法，观察组在对照组的基础上给予转移因子口服液。观察两组疗效、症状改善时间、C-反应蛋白（CRP）和降钙素原（PCT）水平变化、白细胞计数变化及不良反应情况。结果观察组治疗总有效率为92.22%，明显高于对照组的82.22%，差异有统计学意义（P ﹤0.05）；观察组退热时间、咳嗽时间、住院时间为（2.41±0.59）、（4.84±1.56）、（5.25±1.17）d，均明显短于对照组[（3.47±0.48）、（6.45±1.93）、（6.97±1.48）d]，差异有统计学意义（P ﹤0.05）；治疗后，两组 CRP、PCT、白细胞计数水平显著降低，观察组 CRP、PCT、WBC 计数水平显著低于对照组，差异有统计学意义（P ﹤0.05）。结论抗生素序贯疗法联合转移因子能有效治疗儿童急性下呼吸道感染，具有症状改善时间短、炎症恢复快、不良反应少的特点。Objective To investigate the clinical efficacy and safety of antibiotic sequential ther-apy combined with transfer factor in treatment of children with acute lower respiratory tract infection. Methods One hundred and eighty children with acute lower respiratory tract infection were randomly divided into two groups,with 90 cases in each group. Children in control group were given antibiotics sequential therapy,and children in observation group were given antibiotics sequential therapy combined with transfer factor oral solution. The total effective rates,symptoms improvement times,CRP and PCT levels,WBC counts,adverse reactions of the two groups were observed. Results The total effective rate of observation group was 91. 11% ,which was significantly higher than that in control group（82. 22% ）, the difference was significant（P ﹤ 0. 05）;The cooling time,cough time,and hospitalization of observa-tion group were（2. 41 ± 0. 59）,（4. 84 ± 1. 56）,（5. 25 ± 1. 17）d,which were significantly shorter than that in control group[（3. 47 ± 0. 48）,（6. 45 ± 1. 93）,6. 97 ± 1. 48）d],the differences were significant（P ﹤ 0. 05）. After treatment,CRP,PCT,WBC counts levels of the two groups decreased significantly,CRP,PCT,WBC count levels of the observation group were significantly lower than those in control group,the differences were significant（P ﹤ 0. 05）. Conclusions Sequential antibiotic therapy combined with transfer factor can effectively treat children with acute lower respiratory infections, with characteristics of short symptoms improvement time,quicker inflammation recovery,and fewer adverse reactions.

关 键 词：抗生素 序贯疗法 口服转移因子 儿童 急性下呼吸道感染 

分 类 号：R725.6[医药卫生—儿科]