重庆地区正常育龄期女性雄激素水平初探  

Preliminary exploration of androgen levels of healthy reproductive-age women in Chongqing

作　　者：杜婷婷[1] 周恍 杨淑敏[1] 朱启波[1] 王越[1] 胡金波[1] 甄乾娜[1] 李启富[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,重庆400016

出　　处：《重庆医科大学学报》2015年第6期824-827,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81370954;81200294;81170751);国家临床重点专科建设项目

摘　　要：目的：了解重庆地区正常育龄期女性总睾酮（total testosterone,TT）、游离睾酮（free testosterone,FT）、游离睾酮指数（free androgen index,FAI）、硫酸脱氢表雄酮（dehydroepiandrosterone sulfate,DHEAS）的个体值分布范围。方法：于2007年10月至2012年8月招募健康成年女性121名,检测其血清TT、DHEAS水平,计算FT（calculated free testosterone,c FT）及FAI的值,对正态分布指标采用（x±1.96 s）、对非正态分布指标采用百分位数法（P2.5和P97.5）建立各指标95%的个体值分布范围。结果：（1）成年女性雄激素指标TT、c FT、DHEAS呈正态分布,平均水平TT为（0.46±0.16）ng/ml,c FT为（5.92±2.80）pg/ml,DHEAS为（222.81±86.82）μg/dl,FAI呈右偏态分布,中位数及四分位间距为2.60%（1.87%~3.56%）。（2）TT的95%个体值分布范围为（0.15~0.77）ng/ml,c FT的95%个体值分布范围为（0.43~11.40）pg/ml,FAI的95%个体值分布范围为0.90%~9.34%,DHEAS的95%个体值分布范围为（52.64~392.98）μg/dl。结论：初步建立了重庆地区正常育龄期女性TT、c FT、FAI、DHEAS的个体值分布范围。Objective：To explore the individual reference intervals of total testosterone（TT）,free testosterone（FT）,free androgen index（FAI） and dehydroepiandrosterone sulfate（DHEAS） of healthy reproductive-age women in Chongqing. Methods：Totally 121 healthy reproductive-age women were enrolled,and serum TT,DHEAS,SHBG were measured,then FT and FAI were calculated.The（x±1.96 s）was calculated as the reference intervals of TT,c FT,DHEAS,and the 2.5th and 97.5th percentiles were calculated as the reference intervals of FAI. Results：（1）TT,c FT and DHEAS were in normal distribution,with levels of（0.46±0.16）ng/ml,（5.92±2.80）pg/ml,（222.81±86.82）μg/dl,respectively. However,FAI was in skewed distribution with the median and interquartile spacing of 2.60%（1.87-3.56）%.（2）The 95% individual reference intervals of TT,c FT,FAI and DHEAS were（0.15-0.77）ng/ml,（0.43-11.40）pg/ml,（0.90-9.34）%,（52.64-392.98）μg/dl,respectively. Conclusion：The individual reference intervals of TT,c FT,FAI and DHEAS of healthy reproductive-age women in Chongqing are preliminarily established.

关 键 词：育龄期女性 雄激素 个体值分布范围 

分 类 号：R588.6[医药卫生—内分泌]