丙泊酚预防高血压脑出血术后再出血的临床可行性研究  

Study on clinical feasibility of propofol for predicting re-bleeding in postoperative patients with hypertension brain hemorrhage

作　　者：徐陶[1] 甘辞海[1] 

机构地区：[1]泸州医学院附属医院ICU,四川泸州646000

出　　处：《现代医药卫生》2015年第16期2423-2425,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨高血压脑出血（HBH）术后患者采用丙泊酚镇静治疗预防再出血的可行性。方法选取2014年1~12月该院收治的HBH手术患者46例,将其分为治疗组（23例）和对照组（23例）,两组患者手术结束后即转入ICU,予以连续监护治疗48 h。对照组采用止血、脱水、神经营养等治疗,治疗组在对照组治疗的基础上,静脉泵入丙泊酚,监测两组患者术后1、2、4、8、12、16、24、48 h镇静躁动评分（SAS）、收缩压（SBP）、舒张压（DBP）、脉搏血氧饱和度（Sp O2）、心率（HR）、降压药用量和再出血情况。结果治疗组SAS、SBP、DBP、HR、降压药用量及再出血发生率与对照组比较,差异均有统计学意义（P〈0.05）,而两组Sp O2比较,差异无统计学意义（P〉0.05）。结论高血压脑出血患者术后在严密监护下采用丙泊酚镇静是安全、有效的,能平稳控制血压,有效降低再出血的发生率。Objective To study the feasibility of adopting the propofol sedation therapy to prevent re-bleeding in post operative patients of hypertensive brain hemorrhage（HBH）. Methods Forty-six operative patients with HBH in our hospital from January to December 2014 were randomly selected and divided into the treatment group（23 cases） and the control group（23 cases）.All the patients in the two groups were transferred into ICU immediately after operation and were given the continuous monitoring and treatment for 48 h. The control group adopted the therapy of hemostasis,dehydration and neural nutrition,while on this basis the treatment group was given propofol by the venous pumping. The sedation agitation scale（SAS） score,SBP,DBP,HR,Sp O2 at postoperative 1,2,4,8,12,16,24,48 h were monitored in the two groups. The dosage of anti-hypertensive drugs and re-bleeding situation were also monitored. Results The differences of the SAS score,SBP,DBP,HR,dosage of anti-hypertensive drugs and re-bleeding situation in the treatment group had statistical significance compared with the control group（P0.05）,but Sp O2 had no statistically significant difference between the two groups（P0.05）. Conclusion Adopting the propofol sedative therapy in the postoperative patients with HBH is safe and effective under strict monitoring,can smoothly control the blood pressure and effectively reduce the incidence of re-bleeding.

关 键 词：二异丙酚 高血压 脑出血 血压 手术后期间 

分 类 号：R493[医药卫生—康复医学]