血清PAPP—A、PIGF和sFlt-1在子痫前期患者中的表达及意义  

Changes of Serum Pregnancy-Associated Plasma Protein-A, Placental Growth Factor and Solu- ble Fins-Like Tyrosine Kinase Receptor-1 Concentrations in Preeclampsia Patients

作　　者：陈雪[1] 应豪[2] 杨慧琳[1] 

机构地区：[1]上海市浦东新区妇幼保健院妇产科,上海201206 [2]上海市第一妇婴保健院,上海200040

出　　处：《医学临床研究》2015年第7期1277-1279,共3页Journal of Clinical Research

基　　金：浦东新区卫生系统优秀青年医学人才培养计划（编号：PWRq2012-28）

摘　　要：【目的】探讨血清妊娠相关蛋白A（PAPP—A）、胎盘生长因子（PLGF）、可溶性Fins样酪氨酸激酶1（sFlt-1）在子痫前期患者中的表达及意义。【方法】回顾性分析本院2013年2月至2014年6月收治的82例妊娠妇女的临床资料，包括21例轻度子痫前期患者、16例重度子痫前期患者和45例正常妊娠妇女，分别于四个妊娠阶段（12～15周、20～24周、28～32周，35～37周）采用ELISA法检测患者血清中PAPP—A、PLGF、sFlt-1的浓度水平并比较。【结果】三组血清PAPP—A浓度在28～32周和35～37周比较均有显著性差异（P〈0．05）；轻度和重度子痫前期血清PLGF浓度在20～24周、28～32周、35～37周均显著低于对照组（P〈0．05），重度子痫前期在28～32周、35～37周显著低于轻度子痫前期（P〈0．05）；三组血清sFlt-1浓度在28～32周、35～37周比较均有显著性差异（P〈o．05）。在20～24周、28～32周、35～37周对照组、轻度子痫前期、重度子痫前期sFlt-1／PLGF值依次升高（P〈0．05），且组间比较有显著性差异（P〈0．05）。【结论】血清标志物PAPP—A、PLGF和sFlt—1对子痫前期诊治有较高的参考价值，sFlt-1／PLGF更有优势。[Objective] To explore the expressions and significance of pregnancy-associated plasma protein A （PAPP-A）, placental growth factor （PLGF） and soluble fms-like tyrosine kinase receptor-1 （sFlt-1） in pregnant women with preeclampsia. [Methods] Retrospective analysis was performed for 82 pregnant women from February 2013 to June 2014, including mild preeclampsia （ n =21）, severe preeclampsia （ n = 16） and 45 normal pregnancy （ n =45）. And enzyme-linked immunosorbent assay （ELISA） was employed to measure the serum concentrations of PAPP-A, PLGF and sFlt-1 at four gestational periods of 12-15, 20-24, 28-32 ＆ 35-37 weeks. One way analysis of variation （ANOVA） was used to determine the differences of observation and control groups. [Results] During the first period, all three indicators were similar; during the second period, sFlt-1 and PLGF were useful for distinguishing preeclampsia group from normal group. During third and fourth periods, these indicators were effective for distinguishing preeclampsia group from control group and severe preeclampsia from mild preeclampsia. And the ratio of sFlt/PLGF was a more effective indicator for measuring the difference of these groups. [Conclusion] Serum indicators, such as PAPP-A, PLGF and sFlt-1, are useful in the diagnosis of preeclampsia. However, the ratio of sFlt and PLGF is more effective for diagnosing preeclampsia earlier.

关 键 词：先兆子痫 妊娠相关血浆蛋白A/分析 生长物质/分析 蛋白酪氨酸激酶类/分析 

分 类 号：R714.244[医药卫生—妇产科学]